GI

Describe the clinicopathologic features of benign head and neck tumors, squamous dysplasia, and carcinoma Compare and contrast the common salivary gland tumors Describe the clinicopathologic features of the common non-neoplastic diseases of the oral cavity

Describe the epidemiology and pathogenesis of enterohemorrhagic E. coli. Distinguish the various forms of E. coli infections. Differentiate E. coli and Salmonella using culture media. Diagnose Salmonella infections Describe the clinical characteristics and epidemiology of cholera. Identify the mechanism of action of cholera toxin. Compare Campylobacter and E. coli infections. Characterize the microbial cause of ulcers.

Describe the common presenting symptoms of esophageal motility disorders and what they mean pathologically. Describe the structural pathology of the esophagus and their common associations Describe the esophageal pathophysiology associated with alcoholism and cirrhosis Describe the common causes of esophagitis (infectious, eosinophilic, reflux) Describe the pathophysiology of reflux esophagitis, its outcomes and associations

Describe the structural pathologies of the stomach and their outcomes. Describe acute and chronic gastritis, its causes, pathologic features and possible outcomes. Describe the role Helicobacter Pylori plays in gastric pathology Describe the various types of gastric ulcers, their etiologies, pathologic features and outcomes. Describe the variants of hypertrophic gastropathy and their associations and outcomes.

Describe the common structural anomalies of the bowel (Stenosis \ atresia, duplication, Meckel, Omphalocele, Malrotation and Hirschsprung disease) Compare and contrast the causes of diarrhea (secretory, osmotic, exudative, dysentery, and malabsorption) Describe the pathogenesis and pathologic findings (including lab tests) of pseudomembranous colitis Describe the clinicopathologic findings in gluten sensistive enteropathy as well as possible outcomes for refractory disease Compare and contra

1. Describe the syndromes involving gastric acid production and the pharmacological approaches used to modulate gastric acidity 2. List the prototype proton pump inhibitors, H2 antagonists, anti-muscarinics, antacids and mucosal protective agents, describe their mechanism of action, pharmacokinetics, clinical uses, and significant side effects 3. Define peptic ulcers, describe the role that Helicobacter pylori play in inducing peptic ulcers, list the two therapeutic approaches for treatment of

1. Describe the pathophysiology of nausea and vomiting including the afferent and efferent pathways and the role that each plays in the different types of nausea and vomiting 2. List the prototype anti-emetic agents used to control the different types of nausea and vomiting, describe their mechanism of action, and list their significant adverse effects

Describe the most common benign and malignant tumors of the esophagus including causes, associations, pathogenesis and appearances Describe the most common benign and malignant tumors of the stomach including causes, associations, pathogenesis and appearances Describe the role H. pylori infection plays in carcinogenesis Describe the most common benign and malignant tumors of the small bowel including causes, associations, pathogenesis and appearances Describe the most common benign and mal

Identify the common causes of food poisoning and their epidemiology. Describe the pathogenesis of food poisoning with S. aureus. Compare treatment of listeriosis and food poisoning. Diagnose rotavirus infections. Describe the epidemiology of calcivirus (norovirus) infections.

Discuss the common non-infectious entities resulting in liver injury and their clinicopathological characteristics Compare and contrast the clinicopathological characteristics of primary biliary cirrhosis and primary sclerosing cholangitis Describe the clinicopathologic features of fulminant hepatic failure Describe the causes and clinical presentations associated with cirrhosis

Describe the lab test patterns which may indicate poor hepatocyte synthesis Describe the lab test patterns which may indicate direct hepatocyte injury Describe the lab test patterns which may indicate obstructive biliary injury Describe the lab test patterns which may indicate improper bilirubin clearance Describe the lab test patterns which may indicate pancreatitis

1. List the prototype drugs used to treat helminth infections, describe their mechanism of action, their clinical activity, and list their major side effects. 2. List the prototype drugs used to treat amebiasis, describe their clinical activity and their mechanism of action, and list their significant side effects. 3. List the prototype drugs used to treat giardiasis, leishmaniasis, trypanosomiasis and trichomoniasis infections, describe their mechanism of action and clinical activity, and lis

Describe the clinical presentation, PE findings, differential diagnosis and "next best test" for the following disease conditions: PUD, pancreatitis, cholecystitis, diverticulitis, peritonitis, hepatitis, and colon cancer Describe the conditions associated with the following PE findings: 1) Murphy’s sign 2) McBurney’s point tenderness 3) Gray-Turners 4) Cullens 5) Spider angiomas Describe the conditions associated with the following PE findings: 6) Ascites- Fluid wave 7) Signs of peritonit

Describe the clinicopathologic findings in the common non-neoplastic gallbladder disorders Describe the clinicopathologic findings in the common non-neoplastic extrahepatic bile duct disorders Describe the pathologic features of common gallbladder tumors Describe the pathologic features of common extrahepatic bile duct tumors Describe the clinicopathologic findings in and causes of acute and chronic pancreatitis Describe the pathologic features common pancreas tumors (pseudocyst, adenocarci

1. List the prototype drugs used to treat systemic, mucocutaneous, and topical fungal infections, describe their mechanism of action, list their clinical uses, and list their significant side effects.

Learn the basic clinical approach to potentially poisoned patients 2. Learn the significance of common patterns of intoxication 3. Learn the basic approaches to decontamination 4. Learn the specific antidotes for selected intoxications 5. Learn the rationale for removal of absorbed toxicants

Describe the clinical findings and pathophysiology of the common inborn errors of metabolism (Wilson disease, hemochromotosis, alpha-one antitrypsin deficiency) Compare and contrast the clinicopathologic features of benign liver tumors (Hemangioma, focal nodular hyperplasia, adenoma) Compare and contrast the clinicopathologic features of malignant liver tumors (metastasis, cholangiocarcinoma, hepatoceulluar carcinoma)

Describe the clinical findings and pathophysiology of the common inborn errors of metabolism (Wilson disease, hemochromotosis, alpha-one antitrypsin deficiency) Compare and contrast the clinicopathologic features of benign liver tumors (Hemangioma, focal nodular hyperplasia, adenoma) Compare and contrast the clinicopathologic features of malignant liver tumors (metastasis, cholangiocarcinoma, hepatoceulluar carcinoma)