Immunosuppressant and disease modifying Anti-rheumatic drugs:

Question 1

Corticosteroids

Answer 1

bind to receptors in the cell, to alter gene expression to prevent IL-2 and 6 production, as well as inhibiting T cell activation.

Question 2

Azathioprine

Answer 2

inhibits purine metabolism, thus reducing synthesis of RNA and DNA selectively in cells with a high mitotic range.

Question 3

Cyclophosphamide

Answer 3

cross link DNA to prevent it replicating, thus suppressing T and B cells.

Question 4

Mycophenalate mofeteil

Answer 4

converted to MPA which inhibits enzyme guanosine, which is involved in T and B lymphocytes.

Question 5

Calcineurin inhibitors (tacrolimus)

Answer 5

complexes then binds to calcineurin, preventing it from activating nuclear which activates IL-2 transcription.

Question 6

Methotrexate

Answer 6

inhibits DHFR enzyme which converts folate to purines and thymidylate.

Question 7

Sulfasalazine

Answer 7

bacteria in the colon break it down into something else and it is absorbed, it then inhibits T-cell proliferation, IL-2 production and degranulation.

Question 8

Anti-TNF drugs

Answer 8

monoclonal antibodies inhibiting TNF-alpha.

Question 9

Can methotrexate be used to treat rheumatoid arthritis?

Answer 9

hell FUCKING yeah