Anti-clotting drugs:

Question 1

warfarin

Answer 1

inhibits vitamin K which is needed to activate factors 2,7,9 and 10.

Question 2

heparin

Answer 2

binds to anti-thrombin 3 and activates it which leads to the breakdown of factors 2a, 10a and 9a.

Question 3

how can low molecular weight heparin be reversed easily?

Answer 3

protamine sulphate.

Question 4

aspirin

Answer 4

inhibition of COX-1, prevents formation of thromboxane A3 which is released by platelets to signal aggregation and cause vasoconstriction.

Question 5

dipryridamole

Answer 5

inhibits platelet phosphodiesterase , so there is an increase in cAMP, which prevents aggregation.

Question 6

clopidogrel

Answer 6

prevents ADP binding to P2Y12 receptor, thus inhibiting the breakdown of cAMP.

Question 7

Gp2b/3a

Answer 7

prevent platelet cross-linking by fibrinogen.

Question 8

streptokinase

Answer 8

bacterial protein that activates endogenous plasminogen to form plasmin and break down clots.

Question 9

altepase

Answer 9

generates plasmin which breaks down fibrin.