Corticosteroids: Flashcards
1
Q
glucocorticoids (cortisol, prednisolone)
A
stimulates glycogenesis, gluconeogenesis, proteolysis and lipolysis.
2
Q
mineralcorticoids (aldosterone)
A
increase number of ENac channels in the late DCT and collecting duct.
3
Q
why can corticosteroids be used as anti-inflammatory drugs?
A
inhibit B and T cell responses, reduce transcription of cytokines and phagocytes.
4
Q
How do these steroids work? (corticosteroids)
A
crosses cell membrane and binds to a steroid receptor. the steroid then enters the nucleus and binds to the hormone response element on DNA which can switch on/off transcription of proteins.
