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RUSVM Immunology 2016 > Immunomodulation Immunopharmacology > Flashcards

Immunomodulation Immunopharmacology Flashcards

1
Q

Immunomodulation/immunopharmacology

A

Manipulate the immune response via stimulation or suppression of the immune response

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2
Q

Radiation targets and effects

A

Targets DNA and Water- causing DNA mutations, and free oxygen and hydroxyl radicals that damage cells

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3
Q

Corticosteriods targets and effects

A

NF-kB- decreasing gene transcription and cytokine synthesis

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4
Q

Cyclophophasmide targets and effects

A

DNA- suppresses bone marrow

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5
Q

Methotrexate targets and effects

A

dihydrofolate reductase- inhibits the synthesis of thymidine and purine nucleotides

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6
Q

Azatiophrine targets and effects

A

DNA- inhibits DNA and RNA synthesis

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7
Q

Effects of Corticosteroids on Neutrophils

A

decreases chemotaxis, margination, phagocytosis, ADCC, bactericidal activity
inhibits phospholipase A2

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8
Q

Effects of corticosteroids on macrophages

A

decreases chemotaxis, phagocytosis, bactericidal activity, IL-1 and IL-6 production and antigen processing

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9
Q

Effects of corticosteroids on lymphocytes

A

decreased proliferation, T cell response, T cell-mediated cytotoxicity, IL-2 production, lymphokine production

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10
Q

Effects of corticosteroids on complement

A

NONE

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11
Q

Example of corticosteroids in small animal

A

prednisolone and methylprednisolone

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12
Q

Example of corticosteroids in large animal

A

betamethasone, dexamethasone

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13
Q

Examples of non specific immunosuppressives

A

radiation, corticosteroids, cyclphosphamide, methotrexate and axatiophrine

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14
Q

Examples of selective immunsuppressives

A

cyclosporine, tracolimus, rapamycin, mycophenolate, lefunomide, antiserum, antibodies

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15
Q

Cyclsporine effect on teh immune system

A

blocks TH1 response and MHC 1 expression

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16
Q

What drug is ideal treatment in organ transplant and hypersensitivities?

A

cyclosporine

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17
Q

Tracolimus effect on the immune system

A

(inhibits B and T cell response)

18
Q

Rapamycin (sirolimus) targets

A

m-TOR

19
Q

Cyclosprine targets

A

calcineurin

20
Q

Cyclosprine effects calcineurin by

A

inhibits signal transduction and synthesis of IL-2 and IFN-y

21
Q

Tracolimus targets

A

Calcineurin

22
Q

Tracolimus effects calcineurin by

A

inhibits the productin of IL-2, 3, 4, 5 and IFN-y and TNFalpha

23
Q

Rapamycin effects mTOR by

A

blocking stimulatory signals from IL-2, 4, and 6

24
Q

Rapamycin effect on the immune system

A

promotes tolerance and T reg activity

25
Q

Mycophenolate is toxic for what species?

A

dogs- GIT

26
Q

Mycophenolate targets

A

DNA

27
Q

Mycophenolate effects DNA by

A

preventing DNA synthesis, blocks T and B cell proliferation

28
Q

Leflunomide targets

A

DNA

29
Q

Leflunomide effects the immune system by

A

decreasing production of T reg cells

30
Q

Antiserum targets

A

CD3, 4, and 8

31
Q

antiserum effects the immune system

A

by depleting lymphocytes

32
Q

antibodies target

A

CD32

33
Q

antibodies effect teh immune response by

A

inhibiting the humoral immune response

34
Q

Bacille calmette- Guerin targets

mycobacterium bovis

A

TLRs

35
Q

Bacille calmette- Guerin

mycobacterium bovis

A

enhances T and B cell responses

36
Q

Complex carbohydrates

A

activate macrophages

37
Q

Examples of complex carbohydrates

A

zymosan, glucans, lentinans, acemannan

38
Q

Levamisole effects the immune response

A

T cell differentiation an dresponse, increases cytokine proudction and phagocytosis

39
Q

Vitamins A, D and E effect the immune response

A

increasing IL-2 production, increase antimicrobial capacity in macrophages and DC, increase lymphocyte mitosis

40
Q

Cytokines target

A

IL-1, 2, 12 and IFN’s

RUSVM Immunology 2016 (14 decks)

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