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RUSVM Immunology 2016 > Exam 2: Lymphocytes and Co-stimulatory Receptors > Flashcards

Exam 2: Lymphocytes and Co-stimulatory Receptors Flashcards

1
Q

Lymphocytes involved in innate immune response

A

Nk cells

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2
Q

Lymphocytes involved in cellular immune response

A

T cells

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3
Q

Lymphocytes involved in humoral immune response

A

B cells

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4
Q

CD lymphocytes receptors for CD3 found in

A

T cells

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5
Q

CD lymphocytes receptors for CD4

A

Helper t cells

Receptor for MHC II

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6
Q

CD lymphocytes receptors for CD8

A

Cytotoxic T cells

Receptor for MHC I

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7
Q

Integrins

A

Heterodimeric proteins that prolong and stabilize cell itneracitons and allows successful antigen recognition

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8
Q

Selectins

A

regulate immigration of lymphocytes into tissues (P, L and E selectin)

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9
Q

Lymphocyte Mitogens

A

sitmulate lymphocytes to divide

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10
Q

These are molecules/receptors that can regulate the lymphocyte function:

a. Cytokines
b. Antibodies
c. Complement
d. Antigen
e. All teh above

A

E. all the above

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11
Q

CD4 and CD8 are expressed on B cells and NK cells. T/F

A

False

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12
Q

Helper T Cells Function

A

regulate immune response

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13
Q

Cytotoxic T cells Function

A

Destroy cells expressing endogenous antigens

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14
Q

Regulatory T Cells Function

A

Control everything

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15
Q

B Cells Function

A

produce antibodies

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16
Q

Immunoglobulin Superfamily Properties:

A
  • found on all cell surfaces
  • none have enzymatic activity
  • many cellular responses are triggered by 2 interactions between 2 different members of the superfamily (TCR and MHC)
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17
Q

TCR alpha/beta most abundant in

A

humans, mice and most non-ruminants

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18
Q

TCR gamma/delta most abundant in

A

calves, lambs and piglets

19
Q

B1 integrins (CD29/CD49)

A

Fibronectin, laminin, Collagen

20
Q

B2 integrins (CD11/CD18)

A

ICAM-1

21
Q

Lymphocyte Mitogens

A

PHA- phytohemagglutinin, LPS- lipopolysaccharide, Con A- Concanvalin A, Pokeweed, BCG- Bacille Calmette-Guerin

22
Q

Complementary Determining Region

A

a binding groove that comes in contact with antigen on the variable domain of the TCR

23
Q

What are the signal transducing proteins on the T cell?

A

CD3 Complex: made up of 5 protein dimers (gamma, delta, epsilon, L, N)
*protein dimers

24
Q

80% of T cell CD3 complex protein sequence

A

alpha, beta- gamma, epsilon- delta epsilon- zeta, zeta

25
Q

CD4 on TH2 cells bind to

A

MHC II on APC

26
Q

CD8 on Tc Cells bind to

A

MHC I on virus infected or abnormal cells

27
Q

CD4/ CD8 function to

A
  • promote T cell responses

* link T cell to APC, to ensure an active signal between the cells

28
Q

What part of the TCR-CD3 recognizes antigen and MHC?

A

TCR alpha

29
Q

What part of the TCR- CD3 recognizes antigen?

A

TCR beta, gamma, delta

30
Q

What part of the TCR- CD3 is the signal transducer?

A

CD3 gamma, delta, epsilon, zeta, nu

31
Q

what part of the TCR- CD3 recognizes MHC II?

A

CD4

32
Q

What part of the TCR-CD3 recognizes MHC I?

A

CD8

33
Q

CD80 is found on

A

dendritic cells, macrophages and activated B cells

34
Q

CD86 is found on

A

B cells

35
Q

The binding of antigen to TCR stimulates T cell expression of

A

CD40 ligand

36
Q

The CD40 ligand on the T cells stimulates expression of (blank) on the APC.

A

CD40

37
Q

The CD40 binding CD40 stimulates expression of (blank) on T cells and (blank) on APC.

A

CD28/152 on T cell

CD80/86 on APC

38
Q

Ligand CD 152 binding to CD 80/86 causes

A

T Cell suppression: production of in doleamine dioxygenase which destroy tryptophan. Absence of tryptophan –> T cells can’t respond to antigen–> T cell response is terminated

39
Q

Ligand CD28 binding to CD86 causes

A
  • eight-fold activation

* T cells IL-2: upregulate cell survival genes, increase energy metabolism, promotes T cell division

40
Q

The variable domain of the TCR is explicit for binding a specific antigen. T/F

A

False

41
Q

TCR, BCR, MHC1 and MHC2 are not members of the IG superfamily. T/F

A

False

42
Q 
If a processed and presented antigen bind in a correct manner on a T cell. T cell is activated and initiates the immune response by: 
A.cytokine production
B. Mitosis
C. Cell differentiation
D. All the above
A

D. All the above

43
Q

CD3 is found in all T Cells and it has a main role in the signal transduction into the T cell. T/F

A

True

RUSVM Immunology 2016 (14 decks)

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