Exam 2: Regulation of Immune Response Flashcards
How often do T and B cells generate self-antigen receptors
50% of the time
Tolerance
no immune response to a specific antigen
What are the two types of tolerance?
Central and peripheral
Central tolerance
immature self reactive lymphocytes within thymus, bursa or bone marrow die or alter their receptor specificity
Peripheral tolerance
Mature lymphocytes that encounter self-antigens are turned off or suppressed by T reg cells
IL-10 functions to
suppress macrophages, Th1 cells, Th2 cells, Treg cells, DCs, Nk cells, Th17
Transforming growth factor beta
regulates t cell activation, macrophages, B cell function
What is negative selection of T cells?
T cells with non functional TCR
What is positive selection of T cells?
Ensures that T cells that recognize self-MHC molecules survive
Where does central tolerance NOT develope?
in the tissues like the brain, eye or testis, because those cells do not travel to the thymus
What is immune paralysis?
When High doses of antigen induce clonal anergy.
What is clonal anergy?
the prolonged antigen specific suppression of T cell function
Central B cell tolerance involves what events?
VDJ rearrangement, gene conversion, somatic mutation
An inadequate immune response may lead to:
immunodeficiency and increased susceptibilty to infection
An excessive immune response may lead to:
allergies or autoimmunity
