Exam 2: Cellular Immune Response II Flashcards
Immunological synapse is made up of:
C Smac, P smac, S smac
C- Smac central Supramolecular activation cluster
Th1 contains MHC and TCR, CD3
Inner P-Smac periphery supramolecular activation cluster
CD2/48
Outer P-SMAC P-Smac periphery supramolecular activation cluster
CD45 and adhesion molecules,ICAm-1 and LFA-1
Th cell types are distinguished by?
their cytokine production
Th1 cells secrete which two cytokines to promote cellular immune response?
IL-2 and IFN gamma
IL-2 functions
activate T cells, B cells, NK cells and macrophages
IFN-gamma functions
inhibit Th2 cells, stimulate Th1 cells, actiavte NK cells and macrophages, acts as antiviral
IL-4
stimualtes B cell growth and differentiation, activates mast cells
IL-5
stimulates B cell growth, mobilizes and activates eosinophils
IL-9
T cell growth factor
IL-13
stimualtes B cell growth and suppresses macrophage functions
IL-10
inhibits Th1 cell function and suppresses macrophage function
TH2 secretes which cytokines to promote the humoral immune resposne
IL: 4, 5, 9, 10, 13
IL-2
promotes B cell proliferation and Th1 activation
Th0 reacts to which cytokine to become TH2?
IL-4
Th0 reacts to which cytokine to become TH1?
IL12
TH 17 reacts to which cytokines to determine its function
IL-6, 21, 23 and TGF- beta
What are the two major functions of TH17?
produce proinflammatory cytokines and act as potent B cell helpers
Memory T Cell, Type 1
- secrete IFN-gamma and act as helper cell
* short lived because immune system takes em out
Memory T Cell, Type 2
- do not secrete IFN-gamma
- long lived, resistant to apoptosis
- central and effector memory T cells
Cellular Immune Response is directed to eliminate:
a. cancer cells
b. intracellular parasites
c. intracellular bacteria
d. all of the above
e. a and C
D. all the above
Is the cellular immune response involved in the rejection of transplanted organs and/or tissue grafts? T/F
True
