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RUSVM Immunology 2016 > Exam 2: Cellular Immune Response II > Flashcards

Exam 2: Cellular Immune Response II Flashcards

1
Q

Immunological synapse is made up of:

A

C Smac, P smac, S smac

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2
Q

C- Smac central Supramolecular activation cluster

A

Th1 contains MHC and TCR, CD3

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3
Q

Inner P-Smac periphery supramolecular activation cluster

A

CD2/48

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4
Q

Outer P-SMAC P-Smac periphery supramolecular activation cluster

A

CD45 and adhesion molecules,ICAm-1 and LFA-1

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5
Q

Th cell types are distinguished by?

A

their cytokine production

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6
Q

Th1 cells secrete which two cytokines to promote cellular immune response?

A

IL-2 and IFN gamma

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7
Q

IL-2 functions

A

activate T cells, B cells, NK cells and macrophages

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8
Q

IFN-gamma functions

A

inhibit Th2 cells, stimulate Th1 cells, actiavte NK cells and macrophages, acts as antiviral

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9
Q

IL-4

A

stimualtes B cell growth and differentiation, activates mast cells

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10
Q

IL-5

A

stimulates B cell growth, mobilizes and activates eosinophils

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11
Q

IL-9

A

T cell growth factor

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12
Q

IL-13

A

stimualtes B cell growth and suppresses macrophage functions

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13
Q

IL-10

A

inhibits Th1 cell function and suppresses macrophage function

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14
Q

TH2 secretes which cytokines to promote the humoral immune resposne

A

IL: 4, 5, 9, 10, 13

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15
Q

IL-2

A

promotes B cell proliferation and Th1 activation

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16
Q

Th0 reacts to which cytokine to become TH2?

A

IL-4

17
Q

Th0 reacts to which cytokine to become TH1?

A

IL12

18
Q

TH 17 reacts to which cytokines to determine its function

A

IL-6, 21, 23 and TGF- beta

19
Q

What are the two major functions of TH17?

A

produce proinflammatory cytokines and act as potent B cell helpers

20
Q

Memory T Cell, Type 1

A
  • secrete IFN-gamma and act as helper cell

* short lived because immune system takes em out

21
Q

Memory T Cell, Type 2

A
  • do not secrete IFN-gamma
  • long lived, resistant to apoptosis
  • central and effector memory T cells
22
Q

Cellular Immune Response is directed to eliminate:

a. cancer cells
b. intracellular parasites
c. intracellular bacteria
d. all of the above
e. a and C

A

D. all the above

23
Q

Is the cellular immune response involved in the rejection of transplanted organs and/or tissue grafts? T/F

A

True

RUSVM Immunology 2016 (14 decks)

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