Exam 2 Autoimmunity/ Immunodeficiency

Question 1

What are factors related with autoimmunity?

Answer 1

sex, age and viruses

Question 2

What are the two types of autoimmunity?

Answer 2

inability to regulate the immune response or abnormal immune response to normal antigen

Question 3

autoimmunity

Answer 3

immune systems self reactive response

Question 4

Autoimmunity can be causes by

Answer 4

hidden antigens (testis, RBC, etc), Molecular changes in Ab or infections (retrovirus)

Question 5

Cross reaction with self antigens causes

Answer 5

the production of self antigen when exposed to foreign antigen

Question 6

What are predisposing factors for hypersensitivity reactions?

Answer 6

genetics, breed and intestinal microflora

Question 7

Myastenia gravis is an autoimmune disease in which,

Answer 7

myastenia gravis blocks receptors for acetylcholine, causing muscle paralysis

Question 8

What is the difference between autoimmunity and immune suppression?

Answer 8

Autoimmunity is the immune system reacting to itself, where immune suppression is decreasing the immune response

Question 9

What are levels of primary immunodeficiencies?

Answer 9

Failure of:

1. pluripotent stem cells
2. committed stem cells
3. T cell development
4. B cell development
5. B cell maturation to plasma cells
6. production of selected Igs classes
7. production of functional phagocytic cells
8. production of complement molecules

Question 10

Primary immune deficiencies are primarily caused by

Answer 10

gene defects

Question 11

Secondary immune deficiencies are primarily caused by

Answer 11

chronic diseases

Question 12

Primary immunodeficiences can be treated with:

Answer 12

bone marrow transplantation, transplant of heterologous stem cells, or gene therapy

Question 13

Thymic aplasia is what kind of immune deficiency?

Answer 13

primary immunodeficiences

Question 14

Thymic aplasia is caused by what?

Answer 14

lack of a thymus or thymus doesn’t develope, causing no humoral immune response

Question 15

autoantigen

Answer 15

self-antigens; that are components of the host’s own body and recognized by the immune system

Question 16

alloantigen

Answer 16

antigens carried by foreign cells or tissue from a genetically unrelated member of the same species

Question 17

xenoantigen

Answer 17

antigens that are present in graft tissue derived from different species

Question 18

Privileged organs/tissues include

Answer 18

anterior chamber of the eye, cornea, thymus, testes, brain