Immunology and Serology Flashcards
the study of all the aspects
of the immune system
immunology
a division of immunology that
specializes in the laboratory detection &
measurement of antigens & antibodies
serology
Specific production of antigen;
no false positives
specificity
The binding of antigen to a specific
antibody plays an important role in the
diagnosis of diseases using the different
tests
the principle of immunology and serologic methods
The action of an antibody when it
cross-links multiple antigens producing
clumps of antigens
agglutination
it is a stage of agglutination that represents the physical attachment
of antibody molecules to antigens and becomes sensitive
sensitization
stage of agglutination that establish of cross-links between
sensitized particles & antibodies, resulting in aggregation and visible to the naked eye, also clumping
lattice formation
what are the type of agglutination reactions and their examples?
direct agglutination - blood typing
passive/indirect - rheumatoid factor latex test
reverse passive - c-creative protein test
Competition between particulate &
soluble antigens for limited
antibody-combining sites.
agglutination inhibition
lack of agglutination mean positive
agglutination inhibition
Branch of immunology which deals with
the uses of immunologic principles to
study & identify the different blood groups
immunohematology/blood banking
who discovered the ABO blood group?
karl landsteiner
in what year did the ABO blood group discovered?
1900
who discovered the blood type AB?
Alfred von De Castello & Adriano Sturli
direct or forward typing
cell typing
backward, reverse, indirect
typing
serum typing
Second most important blood group
system after the ABO blood group system
RH blood group system
the RH blood group system is derived from?
Rhesus macaque monkey
what are the 5 important RH antigens?
D,C, E, c and e
what is the most important and immunologic antigens among 5?
D
Patient serum + Donor RBC (PS-DR)
major crossmatch
Patient RBC + Donor serum (PR-DS)
minor crossmatch
it detects antigen
forward
it detects antibodies
backward
