Immunology and Serology Flashcards
What is an antibody?
protein produced by a plasma cell in the lymphatic system or bone marrow
What is serology?
study of serum reactions between an antigen and its antibody
Innate immune system aka
passive immunity
Adaptive immunity includes _______________.
a “memory” that makes future responses against specific antigen more effective
The Innate immune system does not possess ________.
a “memory”
Acquired immune system aka
active immunity
What does the Humoral part consist of?
B cells
What does the Cell Mediated part consist of?
T cells
How are antibodies produced?
B cells are stimulated by antigens
What are the 5 majors classes of antibody proteins called?
immunoglobulins
What are antibody proteins produced by?
produced by plasma cell
What is measured to diagnose failure of passive immunity?
IgG
What antibody protein can cross the placenta?
IgG
Which antibody protein is the most abundant?
IgG
Which antibody protein is the first to be activated in an initial attack of antigen?
IgM
IgM is the ____________________.
primary immune response
Where is IgA found?
on mucous membranes and in colostrum
What is IgA stimulated by?
IN vax
What does IgD do?
activates and suppresses lymphocyte activity
Where is IgD found?
in large quantities in cell membrane of lymphocytes
What is the function of IgD?
unknown function
What is IgE?
mediator in allergic responses and parasitic infection
Helper T cells have no ___________.
no cytotoxic or phagocytic activity
What are the 3 types of T cells?
Killer (cytotoxic) T cells, Helper T cells, Suppressor T cells
What causes the Suppressor T cell population to increase?
allergy shots
In puppies and kittens, where does a majority of immunoglobulins come from?
95% of circulation immunoglobulins come from the absorption of colostrum shortly after birth
Phagocyte deficiencies respond poorly to ______.
antibiotics
What is the #1 cause of death in dogs?
tumors
What is one of the prevalent tumors in dogs and cats?
lymphomas
What is sensitivity?
proportion of positives that are correctly identified
What is specificity?
proportion of negatives that are correctly identified
What is the advantage of ELISA microwells?
you can batch samples (run one test on multiple patients)
What does a RIM do?
use signal generating component “colloidal gold”
What is an example of a RIM test?
Witness HW test
What is tuberculosis caused by?
mycobacterium bovis (m. bovis)
What are the 3 type of tuberculosis?
human, avian, bovine
