Hematology Flashcards
What is the function of blood?
transports, controls water and pH, maintains body temperature, and regulates electrolytes
What does blood transport?
oxygen and carbon dioxide, waste products, nutrients, enzymes, hormones, plasma proteins (fibrinogen), and toxins
What is normal blood pH range?
7.35 - 7.45
How does blood regulate electrolytes?
excessive salt is sent to renal system and expelled from body
What is blood made up of?
erythrocytes, leukocytes, thrombocytes, plasma/serum
What are erythrocytes?
red blood cells
Where are RBC’s produced?
bone marrow
What is the function of RBC’s?
carries oxygen and waste from tissues
What do RBC contain?
hemoglobin
What are leukocytes?
white blood cells
Where are WBC’s produced?
bone marrow
In a blood sample, where can WBC’s be found?
buffy coat
Where do WBC’s circulate?
the blood and lymphatic system
What are the five different types of leukocytes?
basophils, eosinophils, neutrophils, lymphocytes, and monocytes
What does a high WBC count mean?
infection
What does a low WBC count mean?
bone marrow deficiency and viral disease
What are thrombocytes?
platelets
What are thrombocytes produced by?
megakarocyte
What do thrombocytes control?
bleeding, helps to clot blood
What is plasma?
straw colored fluid in which the blood cells are floating
What does plasma contain that differentiates it from serum?
protein
What is plasma made up of?
90% water and 10% solutes
What electrolytes are in plasma?
K, Ca, Cl, and Na
What does plasma do (besides help clotting)?
helps maintain body temperature by transporting blood cells and maintain pH
What is serum?
plasma without protein
What produces fibrinogen?
produced in the liver
How are CBC’s preformed?
manually or by automated analyzers
What does a CBC consist of?
RBC count, PCV, TP, WBC count, reticulocytes, HgB concentration, RBC indices (MCV, MCH, MCHC), and blood smear
What is complete RBC count?
estimated number of RBC in circulating blood
What is PCV?
the proportion of blood that is occupied by RBC
What is TP?
the measurement of all the plasma proteins in blood
What does TP determine?
how well the liver in performing it’s job of making the protein
High TP = _____ water intake
low
Low TP = _____ water intake
high
What is a complete WBC count?
estimate of WBCs on circulating blood
What is a blood smear?
smear of blood on a slide that enables us to grossly examine the cells
What is a reticulocyte count?
number of immature RBCs in circulating blood, not performed unless indicated to do so
What is HgB concentration?
how much HgB is in one RBC
What are RBC indices?
indicate degree of anemia in patient
What 5 parts does a spun down hematocrit tube have?
meniscus, plasma, buffy coat, packed RBC, clay
What is a dog’s normal PCV?
35-55%
What is a cat’s normal PCV?
30-45%
What is a dog and cat’s normal TP?
6-7.4g/dL
What proteins can be found in plasma?
fibrinogen, albumin, and globulin
What % of TP is made up of Albumin?
35-50%
What % of TP in made up of Globulin?
~35%
What % of TP is made up of fibrinogen?
3-6%
What is hemoglobin made up of?
4 parts iron and 1 part protein
What is the formula to calculate HgB concentration?
PCV/3
What is the formula to calculate RBC count?
PCV/6
What is the formula to calculate MCV?
PCV/RBC count x 10
What is microcytic?
low MCV cells
What is macrocytic?
high MCV cells
Normocytic
normal MCV cells
What is the formula to calculate MCH?
HgB/RBC count x 10
What units is MCV measured in?
femtoliter (fl)
What units is MCH measured in?
picograms (pg)
What is MCV?
measure of the average size of the erythrocytes
What is MCH?
measure of the average weight of hemoglobin contained in the average RBC
What is MCHC?
measure of the concentration of HgB in the average RBC
What is the formula to calculate MCHC?
HgB/PCV x 100
What units is MCHC measured in?
g/dL
What is hypochromic?
MCHC is below normal (less than average concentration of HgB)
What is hyperchromatic?
MCHC is above normal (more than average concentration of HgB)
What is normochromic?
MCHC is normal (normal concentration of HgB)
What are the units for RBC count?
x10^6/ul
What are the units for hemoglobin concentration?
g/dl