Immunology Flashcards
What type of bacteria express LPS?
Gram negative
What is the PRR for LPS?
TLR4
Where do naive B cells reside in the lymph nodes?
Cortex
Where do naive T cells reside in the lymph nodes?
Paracortex
Through what do naive lymphocytes enter the lymph nodes?
High endothelial venules
What is IgM specialised for?
First responder. Activates classical pathway of complement cascade.
What is IgA specialised for?
present in mucosa. Neutralises
What is IgD specialised for?
rarest. Expressed on B cells
What is IgG specialised for?
Most common. Neutralises and opsonises. Antibody dependent cell-mediated cytotoxicity (ADCC); flag for NK cells
What is IgE specialised for?
Elevated in parasitic infections and allergy. Degranulation.
CD4+ T cells are also known as what type of T cell?
Helper T cells
CD8+ T cells are also known as what type of T cell?
Cytotoxic T cells
How long after entering tissue until neutrophils die?
Within hours
Define Type II hypersensitivity
IgM and IgG are generated against host antigens on cell surface or ECM. Igs then initiate complement or disrupt normal funciton.
Define Type III hypersensitivity
IgM and IgG are generated and form immune complexes that can’t be cleared and thus lodge in capillaries or glomeruli