Immunology 2 Flashcards
Primary vs Secondary Disorder
Primary - defect involving T or B cells or lymphoid tissues (inherited in the genesis of the immune system), genetic deficiencies of innate immune (complement proteins and phagocytes)
Secondary - disease or infection that depresses or block immune response (infection, age, malnutrion, chemo, autoimmune disorders, immunosuppression)
AIDS
Acquired Immunodeficiency Syndrome
caused by HIV (RNA) a retrovirus
mainly attacks CD4, depleting T cells but also infects macrophages, B cells, dendritic cells and microglial cells
HIV-1 causes global epidemic bc its more readily transmitted
Transmission of AIDs
- contaminated blood
- sex
- maternal to child
not transmitted by fomites, household or social contact
General Clinical manifestation of AIDS
Stages of infection vary from acute to asymptomatic to symptomatic and correlate with the level of CD4 (lymphocyte) counts
Acute infection of AIDS
happens first
1-6 weeks, flu-like symptoms and lymphadenopathy (swelling of lymph nodes)
antibody tests remain NEGATIVE
Asymptomatic phase of AIDS
1-20 years
CD4 count of 500 cells/mm or more (going down)
POSITIVE antibody test but no symptoms
seroconversion - emergence of HIV antibodies in blood
Symptomatic phase of AIDS
CD4 count is 200-500 cells/mm (LESS)
- adenopathy (enlarged lymph nodes)
- non specific symptoms like diarrhea, weight loss, fatigue, night sweats and fever
- neurologic symptoms from HIV encephalopathy
Table 7.4? page 1014
Other clinical manifestations of AIDS
- Neurologic manifestations (pain syndromes, peripheral neuropathies
- neuromusculoskeletal
- rheumatologic diseases
- cardiopulmonary diseases
- lipodystrophic syndrome
- AIDs-related lymphoma
-kaposi sarcoma
Pain syndromes with HIV
- pain associated with HIV infection, immunosuppression, opportunistic infections or comorbidities
- pain caused by HIV diagnostic procedures and treatment
- pain unrelated to HIV or its treatment (diabetic neuropathy, discogenic pain, -kaposi sarcoma
Prevention of AIDs (when should you obtain testing?)
- received blood or blood products before 1985
- had sex with multiple partners
- inject drugs and share needles
- had sex with someone who injects drugs or shares needles
- sex without condom with someone with HIV
- share needles for tattooing or body piercing
3 Facts of HIV treatment
- HIV meds cannot cure it, they can promote healthier lives and prolong lives of people with HIV
- combinations of medicines are taken to prevent HIV from advancing to AIDS
- meds can reduce the risk of transmission to others (such as mom to fetus)
Recommended treatment of AIDS
HAART - Highly active antiretroviral therapy
Using at least 3 drugs from different classes to suppress virus
NRTIs, NNRTIs, PIs, fusion inhibitors, etc
HIV Precautions for Health Care Workers
- use protective barriers
- wash hands and Musco membranes after body fluid contamination
- prevent needle or scalpel sticks
- ventilation devices for resuscitation
- if you have open wound or lesion don’t treat or use equipment
- pregnant workers take extra precautions
- occupational exposure to HIV should be followed immediately by eval of the exposure source and PEP
Postexposure prophylaxis (PEP)
urgent medical concern
preventing infection after high risk exposure
What is Chronic Fatigue and Immune Dysfunction Syndrome
CFS used interchangeably with ME (myalgic encephalitis)
illness is not a single disease but combination of factors
subset of chronic fatigue - unexplained fatigue of greater than or equal to 6 months
CFS risk factors
higher prevalence in women, minority groups and people with lower educational attainment and occupational status
mean age of onset is 29-35 years
Pathogenesis of CFS
Explanations were sought out in viral infections, immune dysfunction, neuroendocrine responses, dysfunction of the CNS, muscle structure, exercise capacity, sleep patterns, genetic constitution, personality and neuropsychologic processes
Fig 7.27 Infection control in immune deficiencies
altered defensive mechanisms
infectious agents
revisors
modes of transmission
infection control strategies