Immunology 1 Flashcards
Hematopoietic cells
Stem cells that produce;
myeloid stem cells (makes basophils, eosinophils, neutrophils)
and
lymphoid stem cells (mature into T and B cells)
Neutrophils (role and characterisitcs)
Innate Immune
Also called polymorphonuclear cells (PMNs) bc their segmented nucleus
Increase in number in response to infection and inflammation (first cells to arrive)
Major line of defense against pus-forming bacteria
Phagocytes - engulf bacteria and produce debris
Granulocytes - have enzymes and proteins that kill invading pathogens or threats
Monocytes and MAcrophages
Innate and Adaptive (macro) Immune
long lived cell with bilobed nucleus, originate in bone marrow
In response to infection and inflammation they migrate to the tissue and mature into macrophages
They take over neutrophils and filter the debris they made, kill (phagocytosis) any damaged bacteria or bacteria that was too large for neutrophils
Also eliminate old RBC or dead neutrophils
(They ingest bacteria and use it to express as an antigen on their MHC to signal the T helper cells to respond)
Eosinophils
Innate
Involved in allergic responses and parasitic infections
When invading organisms are too large for neutrophils and macrophages to eliminate, eosinophils surround the pathogen and release the contents of their granules to induce membrane damage and death
granule contents:
histamine: vasodilator
heparin: anticoagulant
cytokines: inflammatory reactions
Basophils and Mast cells
Innate
Both located close to blood vessels and have similar fxn
Basophils - major role in allergic reactions releases substances from their granules
Mast cells -
- involve in allergic reactions, anaphylaxis, wound healing, and against pathogens
- possess granules containing histamine that dilate blood vessels
Both increase blood supply which recruits more phagocytes to the infected site
Erythrocytes and thrombocytes
innate
both responsible for movement and removal of antigens, antibodies and portions of the compliment system
Erythrocytes (RMB) and thrombocytes (platelets)
platelets - hemostasis (stopping bleeding after injury) and thrombosis (blood clots)
Lymphocytes (B and T cells)
Adaptive
B lymphocytes - mature in bone marrow, produce antibodies to neutralize pathogens
T lymphocytes - mature in bone marrow and thymus,
- helper t cells
- cytotoxic t cells
NK cells
Lymphocytes, Mature cells in the blood and spleen
Kill the cells infected with viruses, other intracellular micro-infected cells and tumor cells
- localized to infected tissues in response to inflammatory cytokines
- release cytotoxic granules, create pores in membrane, and activate a programmed death cascade
- release more cytokines to recruit macrophages and initiate adaptive immunity
How are NK cells different that the other lymphocytes (T and B cells)
Unlike T and b cells, NK cells do not express antigen-specific receptors, they express activating and inhibitory receptors on their surfaces that interact with lingads on the target cell
NK cells have special receptors on their surface that help them decide whether to attack a target cell.
After binding, these receptors can either send a “go ahead” signal (activating receptors) or a “stop” signal (inhibitory receptors) based on what they find on the target cell. If a target cell is acting suspiciously (like a virus-infected or cancerous cell), the NK cell will get the “go ahead” signal and attack it.
they use a more general system of activating and inhibitory receptors to determine whether to attack a cell based on its overall condition rather than specific markers. This allows NK cells to quickly respond to a wide range of threats.
Phagocytes
Phagocytes readily ingest pathogens and kill them to protect against infection
two principal families of phagocytes
- neutrophils (granulocytes, short lived 2-3 days)
- monocytes (non-granulocytes, months to years)
those undergoing radio or chemo therapy often have decreased amounts of these and re susceptible to infections
Antigen Presenting cells
Three major categories: Macrophages, dendritic cells, B cells
They display an antigen to a T cell in order to activate it, which enables the body to see and react to antigens that the body is exposed to
*Display antigens on MHC II
Class I can be recognized by cytotoxic T cells (CD8+)
Class II recognized by helper T cells (CD4+)
Macrophages and dendritic cells display the antigen after phagocytosis while B cells present the antigen through receptor-mediated endocytosis
First line of defense
innate immunity
resolve most threats, comprised of early host defense mechanisms
does not remember the interaction with a specific invader, just recognizes repeating patterns of molecular structure that are common to certain classes of pathogens
external and internal defenses
external innate defenses
physical, chemical and mechanical barriers that provide protection against invaders
skin, mucus, peristalsis, coughing, sneezing, stomach acid. cerumen, tears, saliva
internal innate defenses
- cellular components (neutrophils, monocytes/macrophages, NK cells)
- soluble factors (complement system, cytokines, chemokines, acute phase proteins)
chemokines - small cytokines that can chemotactic migration of leukocytes and enhance inflammation
acute phase response - occurs when high levels of proinflammatory cytokines are produced
cytokines - signaling molecules, don’t actually kill pathogens but recruit, organize, signal immune system factors and signal for inflammation
complement system - proteins that kill pathogens or mark them fro destruction, also promote inflammation
Secondary line of defense
Inflammatory response
includes the vascular response, the plasma protein system and the complement system
Vascular response of the secondary line of defense
vasodilation occurs to increase blood flow and decrease blood velocity
increased permeability allows migration of WBCs across vessel walls (diapedesis)
*cellular debris and fluid eventually drain through the lymphatic system, which helps mature B and T cells of the adaptive immune response
Third line of defense
Adaptive (specific) immunity
characterized by specificity and memory
humoral and cell-mediated
Humoral immunity
adaptive
involves the production of antibodies by B cells
These antibodies circulate in the blood and lymph, binding to pathogens, marking them for destruction, and neutralizing toxins