Immune system Flashcards
What happens when in case of a laceration with bacteria or virus entering through
Cut will encounter specific kinds of white blood cells that ingest pathogens by phagocytosis. One type being a macrophage. After consuming ht e pathogen, the macrophage is able to put parts of the ingested antigens on its cell membrane to alert patrolling Cells. The macrophage then takes o the role of Antigen presenting cell.
What cells function as antigen presenting cells
*Macrophages after consuming a pathogen
*Dendritic cells
*B cells
Macrophages
*consume pathogens and display them becoming antigen presenting cells
*produce cell signaling molecules, cytokines
Cytokines function
broadcast the location of pathogens to other white blood cells
histamine function
triggers capillary permeability and vasodilation.
These effects make it easier for more white blood cells to leak from the capillaries into the area in need of defense.
Interferons
Prevent virus replication
External innate immune system
*skin
*hair
*mucus
*earwax
*secretions (acid, salt, enzymes)
*Nomrla flora
Internal innate immune system
*antimicrobials
*inflammation
*interferons
*complement
*phagocytes (including APC)
Adaptive immune system Cytotoxic T cells
kill pathogens
B cells
Adaptive immune system and produce antibodies
helper T cells activated by
APC
T cells undergo maturation in
the thymus and mature T cells become activated into helper T cells, cytotoxic T cells, and memory cells
Helper T cells secrete
interleukins
interleukins
Chemical messengers that trigger the action of other cells
Ex. The attack of forge in cells by cytotoxic T cell
Cell mediated immunity (humoral immunity)
a type of adaptive immunity in which T lymphocytes attack parasitic worms, cancer cells, transplanted tissue, or cells that contain pathogens.
cytotoxic T cells
are specialized to kill infected or abnormal cells. some produce memory t cells that respond to subsequent infections
helper T cells
secrete cytokines that stimulate the division of T and B cels while alerting other types of WBCs
regulatory (suppressor) T cells
inhibit T and B cells to stop the immune response
B cells involved in
humoral-mediated immunity. They encounter freely circulating antigens
plasma cells
secrete antibodies that bind to antigens
memory cells produce
antibodies but only during a subsequent infection
neutrophiles
account for most of the white blood cells in the blood stream. phagocytes that are usually the first to arrive at the site of infection
eosinophils
regulate inflammatory responses and release chemicals that kill foreign invaders, often parasitic worms
mast cells and basophils
both release histamine to promote inflammation and heparin to inhibit clotting
macrophages
largest leukocytes that engulf debris and pathogenic microorganisms
dendritic cells
activate T cells
natural killer cells
not phagocytes; they destroy cells that have been infected with a pathogen by binding to them and releasing granzymes that trigger apoptosis