Immune Flashcards
RA, OA, Stevens-Johnson Syndrome, SLE
Rheumatoid arthritis patho
Chronic systemic autoimmune disorder
S+S of RA
Periods of remission and exacerbation
Joint pain: worse on awakening, improves w/ activity
Symmetric joint involvement: involves wrists and finger joints; tender, swollen, and warm to touch
Systemic symptoms: fatigue, weight loss, anemia
Photosensitive
Labs of RA
Elevated ESR and positive rheumatoid factor
Tx of RA
NSAIDs
Glucocorticoid (not long-term)
Immunosuppressants!!
Physical therapy/occupational therapy
Stop if rash develops
Report fever immediately
OA S+S
Pain worse during or after activity
Hard and bony joints
Lifestyle modifications w/ RA
Avoid repetitive mvts that overuse affected joints
ROM
Alternate hot and cold therapy
Rest periods
Stress reduction
Stevens-Johnsons Syndrome S+S
4-28 days after exposure to trigger
Acute influenza-like prodrome
Rapid-onset erythematous macules/vesicles/bullae
Necrosis and sloughing of epidermis
Mucosal involvement
Triggers of SJS
Allopurinol, abx, anticonvulsants, NSAIDs, sulfasalazine
Tx of SJS
Supportive
SLE triggers
Autoimmune inflammatory disorder
UV
Infx
Emotional/physical stress
Meds (oral contraceptives, sulfa)
S+S of SLE
Constitutional: fever, fatigue, weight loss
Skin: malar rash, hair loss, butterfly rash
Mucous membranes: ulcers
Brain: seizures/psychosis
Lungs: pleuritis
Heart: pericarditis
Kidney: glomerulonephritis
Blood: cytopenias
Blood vessels: DVT
Muscle aches
Swollen, red, painful joints
SLE is
photosensitive
Dx of SLE
Elevated ESR and c-reactive protein
Elevated antibodies of ANA
CBC: anemia, thrombocytopenia, leukopenia
Tx of SLE
Immunosuppressants
Glucocorticoids
Analgesics
Chronic: hydroxychloroquine
Pt teaching of SLE
Limit sun exposure
Fragrance-free and gentle soaps/lotions
Avoid infx
ROM exercises
Avoid spicy/citrus foods if oral ulcers are present
Rest periods
Wait until symptom free for 6 months to attempt pregnancy
Avoid live-attenuated vaxx
