IBD Tutorial Flashcards
What are these two diseases?
What is the proposed mechanism of IBD?
IBD: Defects in intestinal epithelia lead to uptake of ……
This causes activation of ……
Where can chrons disease affect? What are the main sites of infection?
What type of lesions do they cause?
What layers of the gut wall are affected?
With chronicity, fibrosis can lead to ________ _________.
Why is the ulceration in chrons disease considered to be cobblestone like?
What are the arrows showing?
What is ‘creeping fat’ or ‘fat wrapping’?
During active inflammation in chrons disease and UC the mucosal crypts are infiltrated by __________. THis is called _______ ________.
In the transmural inflammation tissue there are a lot of ___________ cells.
Neutrophils, crypt abscesses.
mononuclear
One of the hallmarks of chrons disease is ___________. they are filled with _____ cells like in TB. Unlike TB, these granulomas are _________.
granulomas. Th1 cells. non-caseating
What is a fissure ulcer and how far down does it go?
What can you see in this histology?
What are 5 complications of chrons disease?
Sinus formation: A tunnelling wound or sinus tract is a narrow opening or passageway extending from a wound underneath the skin in any direction through soft tissue and results in dead space with potential for abscess formation.
WHat are 5 complications of chrons disease?
What parts of the GI tract does ulcerative colitis involve?
Rectum and then extends proximally to involve the entire colon. The colonic involvement is continuous with no skip lesions.
What layers of the colon is Ulcerative colitis involved with?
Limited to the mucosa and the superficial submucosa.
What are the arrows showing?
Why are they called ‘pseudo-polyps’ in ulcerative colitis?
What type of IBD is shown and why?
Ulcerative colitis because of the pseudopolyps.
What are the different inflammatory cells seen in this UC histology?
What major complication can occur with UC (which can lead to death) and why?
What is the treatment for these patients?
Clinical presentation of IBD (what is the difference between chrons and UC)
What is the most serious long term consequence for someone with chrons or ulcerative colitis?
How is this monitored?
Dysplasia and malignancy.
