Hypoxic-ishaemic encephalopathy Flashcards
1
Q
Cause
A
Perinatal asphyxia
Progressive hypoxia with hypercapcia and acidosis
Causes: Prolonged uterine contractions Placental abruption Cord compression Poor maternal perfusion Respiratory failure
2
Q
Perinatal features:
A
Continued need for resuscitation at 10 mins
Apgar score <5 at 10 mins
Cord/arterial/capillary pH < 7
3
Q
Signs wihin 24 hours:
A
irritable lethargy coma seizures hypotonia poor reflexes multi-organ failure including heart, lungs, kidneys and liver
4
Q
Investigations
A
Amplitude-integrated EEG - Cerebral function analysis monitoring
Cranial USS - Easily available but less sensitive than MRI F
5
Q
Management
A
Stabilize - including airway management if needed
Check glucose and exclude other causes
Therapeutic hypothermia if moderate or severe
Control seizures
6
Q
Complications
A
Death
Cerebral Palsy
Learning difficulties
