Hypertension Flashcards

1
Q

Hypertension can be classified as a BP over?

A

140/90 mmHg

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2
Q

Hypertension is a risk factor for?

A
  • cerebral haemorrhage
  • atheroma
  • renal failure
  • sudden cardiac death
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3
Q

How is hypertension classified?

A
  • cause ( primary or secondary)

- consequence (benign or malignant)

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4
Q

How is blood pressure calculated

A

= CO X SVR

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5
Q

What factors effect cardiac output?

A
  • heart rate
  • contractility
  • blood volume
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6
Q

What factors effect peripheral resistance?

A
  • vasoconstrictors (angiotensin II or catecholamines)

- vasodilators (nitric oxide or prostaglandins)

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7
Q

Explain the RAAS?

A
  • renin released from kidneys
  • angiotensinogen converted to angiotensin I
  • ACE converts to angiotensin II
  • Vasoconstrictor properties & release of aldosterone
  • salt and water retention
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8
Q

What is salt sensitive hypertension?

A
  • can be a primary cause of hypertension
  • increase in dietary salt intake leads to increase in BP
  • Controlled by reduced salt diet
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9
Q

What is secondary hypertension? name some examples

A
  • underlying disease is implicated

- e.g. renal disease, endocrine disease aortic disease

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10
Q

How does renal disease cause hypertension?

A
  • reduced renal blood flow
  • excess renin release
  • salt and water overload
  • increases BP
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11
Q

Examples of endocrine diseases that can cause hypertension?

A
  • Conn’s syndrome
  • Cushings syndrome
  • pheochromocytoma
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12
Q

What is the effect of Conn’s syndrome?

A
  • excess aldosterone
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13
Q

What is the effect of Cushings syndrome?

A
  • excess corticosteroid
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14
Q

What is benign hypertension?

A
  • serious life theratening morbidity

- asymptomatic

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15
Q

What can benign hypertension cause?

A
  • as it is asymptomatic it can go a long period undetected
  • may lead to left ventricular hypertrophy
  • renal disease
  • cardiac failure
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16
Q

What is the effects of left ventricular hypertrophy?

A
  • increased LV load
  • poor perfusion
  • interstitial fibrosis
  • pulmonary oedema
17
Q

What is a complicated atheroma?

A
  • abnormal accumulation of material in inner layer of arterial wall
18
Q

What is aortic dissection

A
  • injury ‘rip’ to inner layer of aorta allows blood to flow between layers of aortic wall (Creates a false lumen)
19
Q

What is the microvascular effect of hypertension?

A
  • blood vessel wall changes
  • thickening of media in smooth muscle
  • hyaline arteriosclerosis
20
Q

What is arteriolosclerosis

A

Arteriolosclerosis is a form of cardiovascular disease involving hardening and loss of elasticity of arterioles or small arteries and is most often associated with hypertension and diabetes mellitus

21
Q

What should you do before using an automated blood pressure monitor?

A
  • check the pulse

- if irregular do BP manually

22
Q

How do you diagnose hypertension?

A
  • ABPM (2 measurements per hour)

- HBPM (2 consecutive seated, recorded twice a day for atlas 4 days)

23
Q

What are definitions of stage 1 hypertension?

A
  • Clinical BP >140/90mmHg

- ABPM daytime >135/85mmHg

24
Q

What are the definitions of stage 2 hypertension?

A
  • Clinical BP >160/100mmHg

- ABPM daytime >150/95mmHg

25
Q

What are the definitions of severe hypertension

A
  • Systolic >180mmHg

- Diastolic > 110mmHg

26
Q

What additional tests should you preform on someone with hypertension?

A
  • protein urine test
  • blood test to measure glucose, U&Es
  • 12 lead ECG
  • Funduscopy (sometimes)
27
Q

Relationship between weight loss and BP

A
  • for every 1kg lost, 1mmHg drop in BP
28
Q

What drugs can be prescribed for BP?

A
  • Thiazide diuretics
  • ACE inhibitors
  • ARBs
  • CCBs
  • B blockers
  • spironolactone
29
Q

Add or titrate?

A
  • adding a drug is 5 x more effective than titrating
30
Q

What drug should be given in resistance hypertension?

A
  • spironolactone
31
Q

Drug treatment flow for hypertension patient <55yrs

A
  • ACEi or ARBs
    • CCB or Thiazide diuretic
  • ACEi or ARBS + CCB + Thiazide diuretic
32
Q

What is your drug flow treatment for a hypertensive patient >55yrs or from African-Carribean descent?

A
  • CCB

- CCB + Thiazide diuretic or ARBs or ACEi