hyper sensitivity Flashcards
how many hypersensitivity categories
4
what are the antibody mediated hypersensitivity categories
1,2,3
what is category 4 mediated by
T cells
where dose auto immunity fall into (categories)
autoimmune
what is category one (immediate)
IgE
allergy
allergen - activation of IgE secreting B cell - IgE binds to mast cell as a (detonator primer) once allergen re exposed - mast cells released mediators
what do the mediators released by mast cells do
produce cytokines
Immediate reaction
mast cell activation leads to
histamine - vasodilation, broncho constriction
cytokines - inflammation
enzymes
edema
how long before the late phase sets on
2 - 24 hours
what is the morphology of the late phase
inflammatory infiltrate in rich eosinophils, neutrophils and T cells
what are the two IgG mediated hypersensitivities
2 - cell or matrix antigen
3 - soluble
what do type 2 + 3 hypersensitivity lead to
antibody mediated diseases
what is type two
IgG - mediated cytotoxic hypersensitivity
type 3
immune complex-mediated hypersensitivity
type 4
cell mediated hypersensitivity
