Humoral Immune Response II Flashcards
Contrast intracellular and extracellular terminology
Define cell mediated immunity and humoral mediated immunity
Summarize effector function of antibodies
What’s the role of Fab in neutralization ?
What’s the role of opsonization of Fab and Fc?
Give the characteristics of FcyRI
Give the characteristics of FcyRIIA
Give the characteristics of FcyRIIB
Give the characteristics of FcRIIIA
Give the characteristics of FceRI
What is the significance of ADCP?
What do NK cells do?
What do eosinophils do?
What are the complement-dependent cytotoxicity ?
What is the IgG function?
What is IgM?
Whaat is IgA?
What is IgE?
What are the functions of antibodies at special anatomical sites?
What is mucosal immunity?
What is neonatal immunity?
Explain Ig half time expansion in neonates
What viruses undergo immunogenic invasion?
What microbes inhibit complement activation?
What microbes block hyalauronic acid?
Describe the third line of defense of the immune system
What is natural immunity?
Natural immunity: acquired as part of normal life experiences
• Active or passive
What is artificial immunity?
Artificial immunity: acquired through a medical procedure
such as a vaccine
• Active or passive
What is active immunity?
▪ Active immunity: results when a person is challenged with antigen that stimulates production of antibody.
• It creates memory, takes time and is lasting
What is passive immunity?
▪ Passive immunity: pre-formed antibody are donated to an
individual.
• It does not create memory, acts immediately, and is short term.
Breakdown examples of adaptive immunity
Contrast active and passive immunity
What factors go into vaccine development?
Whaat are the most difficult vaccine challenges?
What are whole vaccines?
1) Whole vaccines
• Killed whole bacterial cells or inactivated virus
• Live, attenuated bacterial cells or virus
What are acellular or subunit vaccines?
2) Acellular or subunit vaccine
• Antigens derived from bacterial cells or virus particles
• Typically, surface molecules or neutralized toxins (toxoid)
What are recombinant vaccines?
3) Recombinant vaccine
• Genetically engineered
• Selected genes for microbial antigens are cloned into a vector
What are killed whole bacterial vaccine and inactivated whole viral vaccines?
What is attenuation ?
What’s the significance of live attenuated vaccines?
What’s the significance of acellular and subunit vaccines?
What are the types of recombinant vaccines?
What’s the significant physical aspects of COVID 19?
How do3s an mRNA vaccine function?
Compare the types of vaccines?
Describe the immunization in the fetus and neonate
Describe the timing of production of immunoglobins
What are the types of childhood vaccinations?
