Humoral Immune Response 1

Question 1

Summarize humoral adaptive response

Answer 1

Question 2

What are the in vivo sites for infection of humoral responses?

Answer 2

Question 3

What are antibody responses to different antigens?

Answer 3

Question 4

Contrast T cell dependent and independent immunity

Answer 4

Question 5

Where do T cell dependent and independent immunity occur?

Answer 5

Question 6

Summarize B cell activation

Answer 6

Question 7

How can TI-2 Antigens and Cytokines induce B-cell activation?

Answer 7

Question 8

What is the role of the innate immune system in B cell?

Answer 8

Question 9

Explain signal 1 of B cell activation

Answer 9

Question 10

What’s the significance of co-receptors of B-cell activation?

Answer 10

Question 11

What’s the significance of ITIM?

Answer 11

Question 12

Explain the second signal of TD-B cell activation

Answer 12

Question 13

Describe CD40 & CD40L in B cell activation

Answer 13

Question 14

What’s the significance of Tfh cells?

Answer 14

Question 15

What are in vivo sites for induction of TD humoral responses?

Answer 15

Question 16

What is affinity maturation?

Answer 16

Question 17

What’s the clinical significance of class switching?

Answer 17

Question 18

What are the phases of humoral immune responses TD?

Answer 18

Question 19

Contrast primary and secondary humoral response

Answer 19

Question 20

Describe regulation of cell and humoral mediated immunity

Answer 20

Question 21

What are the B cell pathologies?

Answer 21

Question 22

What are follicular B cells (B-2 cell)?

Answer 22

Follicular B cells (B-2 cell) - Most common type of B cell. Found mainly in the lymphoid follicles of secondary lymphoid organs (SLOs) and circulating in blood. They are responsible for generating the majority of high-affinity antibodies during an infection

Question 23

What are the marginal B cells?

Answer 23

Marginal zone B cells - Found mainly in the marginal zone of the spleen and serves as a first line of defense against blood-borne pathogens. They undergo mainly T cell- independent activation

Question 24

What are B-1 cells?

Answer 24

B-1 cells- Predominantly populate the peritoneal and pleural cavities. Generate natural antibodies (produced without infection) against mucosal pathogens. T cell- independent activation.

Question 25

What are plasmablast?

Answer 25

Plasmablast - A short-lived, proliferating antibody-secreting cell. Result from T cell- independent or -dependent activation of B cells

Question 26

What is a plasma cell?

Answer 26

Plasma cell- A long-lived, non-proliferating antibody-secreting cell. Result from the germinal center reaction from T cell-dependent or -independent activation of B cells

Question 27

What are memory cells?

Answer 27

Memory B cell- Dormant B cell. Their function is to circulate through the body and initiate a stronger, more rapid antibody response (known as the secondary antibody response).

Question 28

What are regulatory B cells?

Answer 28

Regulatory B cells- An immunosuppressive cell type that stops the expansion of pathogenic, pro-inflammatory lymphocytes through the secretion of IL-10, IL-35, and TGF-β

Question 29

What are lymphoplasmacytoid cells?

Answer 29

Lymphoplasmacytoid cell - A cell with a mixture of B lymphocyte and plasma cell morphological features. Pre-malignant and malignant IgM producing cells: IgM monoclonal gammopathy of undetermined significance and Waldenstrom’s macroglobulinemia

Question 30

Summarize this deck

Answer 30