HPV, Papova, and Rhabdoviruses Flashcards
Basic structure of Papovaviruses
Small, non-enveloped double stranded DNA viruses
In what type of cells are HPV virions made?
Only in cornified epithelium
Is HPV integration site specific?
No
What histological changes are seen in HPV infection of epithelial cells of cervix and vagina?
Perinuclear cytoplasmic vacuolization, nuclear enlargment, other changes
What does Gardasil contain, what does it protect against, how many doses is it, and who are intended recipients?
HPV types 16 and 18 (cervical cancer), and HPV types 6, and 11 (genital warts), 3 doses, females age 9 to 26, can also be used for males
Notable human polyomaviruses and what family polyomaviruses are in
JC Virus and BK virus. They are in papovaviridae family
Why might polyomaviruses produce tumors in non-natural hosts but not in natural hosts?
Not entirely known, but perhaps because infections in natural hosts are lytic and those in non-natural are not
What virus is Progressive Multifocal Leukoencephalopathy (PML) associated with?
JC virus (a human polyomavirus)
BK virus is associated with what symptomatology in what particular type of patients?
Hemorrhagic cystitis (bladder inflammation) in bone-marrow transplant patients
Urine from pts with polyoma viruses may contain cells similar to those found in pts with what other virus?
CMV
What is the basic structure of rhabdoviruses?
Bullet-shaped, single stranded RNA genome, enveloped
Two important rhabdoviruses
Rabies (a lyssavirus) and Vesicular Stomatitis Virus (a vesiculovirus)
What is used to differentiate strains of rabies virus?
Reverse Transcriptase PCR (RT-PCR). Formerly done by antigens of the virus Glycoprotein
Two methods of rabies transmission and how it gets into peripheral nerves
Bite and aerosol infection. Thought to enter peripheral nerves via Ach receptor
In rabies infection, occurance of what symptom almost invariably means death will follow?
Encephalitis
