Hormones Flashcards
What is the MOA of Levothyroxine Sodium?
Synthetic T-4
What are the ocular side effects of Levothyroxine Sodium?
Myasthenia Gravis-like (ptosis, diplopia, EOM paresis)
What are the CV and CNS adverse effects of Levothyroxine Sodium?
HTN
Pseudotumor cerebri
Hallucination
What are the indications for Estrone?
Menopause
Breast cancer
Prostate cancer
Osteoprosis prevention
What is the MOA of Estrone?
Binds to estrogen receptors, developing and maintaining female sex characteristics and repro systems
Which two hormone drugs have black box warnings?
Estrone
Yaz
Which two hormone drugs can cause CL intolerance?
Estrone
Yaz
What drug type can interact with Levothyroxine to cause an additive effect?
Sympathomimetics
What drug type can interact with Levothyroxine to cause an antagonistic effect?
Sympatholytics
What is the black box warning for Estrone?
Endometrial Cancer Stroke DVT MI Invasive breast cancer
What are the 6 common adverse effects of Estrone?
Headache/migraine Elevated BP Weight changes Fluid retention CL intolerance Vision changes
What may occur when Estrone interacts with systemic steroids?
Increased adverse effects of steroid
When Estrone interacts with Omega-3’s, what may occur?
Antagonized anti-hyperlipidemic effects
What are the 3 contraindications for Estrone?
Hypertension
Smoker
Migraine
What is the MOA for Yaz?
Suppresses LH and FSH, inhibiting ovulation
What are the severe adverse effects of Yaz?
MI
Stroke
Ocular Lesions
What is the black box for Yaz?
Smoking
CV events
What are the common adverse effects of Yaz?
Headache Weight changes Elevated BP Increased cholesterol CL intolerance
Yaz impairs the metabolism of what drug?
Cyclosporine
What happens when NSAIDs and Yaz interact?
Additive hyperkalemia
Yaz causes what when interacting with Tetracyclines, Penicillins, Cephalosporins, Macrolides, and Quinolones?
Decreased efficacy
What happens when Yaz and Ascorbic acid interact?
Decreased metabolism
What are the contraindications for Yaz?
HTN
Smoking
Migraine
What class of drug is Tamoxifen?
SERM
What is the MOA of Tamoxifen?
Binds to estrogen receptors, producing estrogenic and anti-estrogenic effects
What are the common adverse effects of Tamoxifen?
Dizziness
Headache
VA changes
What are the severe adverse effects of Tamoxifen?
Thromboembolism Stroke Pancytopenia Retinopathy Cataracts
Tamoxifen may increase the levels of which drugs?
Cyclosporine
Steroids
Oxycodone
Which drugs inhibit the hepatic production of the active metabolite of Tamoxifen?
Chlorpheniramine
Macrolides
