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Systemic Pharm > Hormones > Flashcards

Hormones Flashcards

1
Q

What is the MOA of Levothyroxine Sodium?

A

Synthetic T-4

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2
Q

What are the ocular side effects of Levothyroxine Sodium?

A

Myasthenia Gravis-like (ptosis, diplopia, EOM paresis)

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3
Q

What are the CV and CNS adverse effects of Levothyroxine Sodium?

A

HTN
Pseudotumor cerebri
Hallucination

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4
Q

What are the indications for Estrone?

A

Menopause
Breast cancer
Prostate cancer
Osteoprosis prevention

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5
Q

What is the MOA of Estrone?

A

Binds to estrogen receptors, developing and maintaining female sex characteristics and repro systems

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6
Q

Which two hormone drugs have black box warnings?

A

Estrone

Yaz

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7
Q

Which two hormone drugs can cause CL intolerance?

A

Estrone

Yaz

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8
Q

What drug type can interact with Levothyroxine to cause an additive effect?

A

Sympathomimetics

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9
Q

What drug type can interact with Levothyroxine to cause an antagonistic effect?

A

Sympatholytics

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10
Q

What is the black box warning for Estrone?

A 
Endometrial Cancer
Stroke
DVT
MI
Invasive breast cancer
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11
Q

What are the 6 common adverse effects of Estrone?

A 
Headache/migraine
Elevated BP
Weight changes
Fluid retention
CL intolerance
Vision changes
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12
Q

What may occur when Estrone interacts with systemic steroids?

A

Increased adverse effects of steroid

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13
Q

When Estrone interacts with Omega-3’s, what may occur?

A

Antagonized anti-hyperlipidemic effects

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14
Q

What are the 3 contraindications for Estrone?

A

Hypertension
Smoker
Migraine

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15
Q

What is the MOA for Yaz?

A

Suppresses LH and FSH, inhibiting ovulation

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16
Q

What are the severe adverse effects of Yaz?

A

MI
Stroke
Ocular Lesions

17
Q

What is the black box for Yaz?

A

Smoking

CV events

18
Q

What are the common adverse effects of Yaz?

A 
Headache
Weight changes
Elevated BP
Increased cholesterol
CL intolerance
19
Q

Yaz impairs the metabolism of what drug?

A

Cyclosporine

20
Q

What happens when NSAIDs and Yaz interact?

A

Additive hyperkalemia

21
Q

Yaz causes what when interacting with Tetracyclines, Penicillins, Cephalosporins, Macrolides, and Quinolones?

A

Decreased efficacy

22
Q

What happens when Yaz and Ascorbic acid interact?

A

Decreased metabolism

23
Q

What are the contraindications for Yaz?

A

HTN
Smoking
Migraine

24
Q

What class of drug is Tamoxifen?

A

SERM

25
Q

What is the MOA of Tamoxifen?

A

Binds to estrogen receptors, producing estrogenic and anti-estrogenic effects

26
Q

What are the common adverse effects of Tamoxifen?

A

Dizziness
Headache
VA changes

27
Q

What are the severe adverse effects of Tamoxifen?

A 
Thromboembolism
Stroke
Pancytopenia
Retinopathy
Cataracts
28
Q

Tamoxifen may increase the levels of which drugs?

A

Cyclosporine
Steroids
Oxycodone

29
Q

Which drugs inhibit the hepatic production of the active metabolite of Tamoxifen?

A

Chlorpheniramine

Macrolides

Systemic Pharm (15 decks)

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