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Systemic Pharm > Cancer > Flashcards

Cancer Flashcards

1
Q

What are the indications for Methotrexate?

A

RA
Psoriasis
Choriocarcinoma

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2
Q

What is the MOA of methotrexate?

A

Folic acid analog that inhibits HGFR, and prevents FH4
Inhibits lymphocyte formation
Activates adensoine pathways

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3
Q

What is the serious adverse effect of Methotrexate?

A

Neurotoxicity

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4
Q

What is the black box warning for Methotrexate?

A

Death
Monitor bone marrow, liver, lungs, and kidneys for opportunistic infections
Potentially fatal myelosuppression with NSAIDs. Cipro, and penecillins

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5
Q

What drug combines with Methotrexate to cause elevated levels?

A

Tetracyclines

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6
Q

What happens when Methotrexate interacts with Ganciclovir or steroids?

A

Additive myelosuppression

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Systemic Pharm (15 decks)

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