GI

Question 1

What is the MOA of Esomeprazole?

Answer 1

Proton pump inhibitor that inhibits gastric parietal cell H+/K+ATPase, inhibiting gastric acid secretion

Question 2

What are the serious adverse effects of Esomeprazole?

Answer 2

SJS

TEN

Question 3

What are the common adverse effects of Esomeprazole?

Answer 3

HA
Constipation or diarrhea
Xerostomia
Flatulence

Question 4

What are the indications for Esomeprazole?

Answer 4

GERD
Gastric Ulcer prophy
Hypersecretory disorders
H. pylori infection

Question 5

Esomeprazole can impair the absorption of what?

Answer 5

Azoles

Certain antivirals

Question 6

What may occur when Esomeprazole and CAIs interact?

Answer 6

Exacerbation of Hypomagnesemia

Question 7

What are the indications for Cimetidine?

Answer 7

GERD
Peptic Ulcer
Dyspepsia

Question 8

What is the MOA of Cimetidine?

Answer 8

H2 blocker that selectively antagonizes parietal cell H2 receptors

Question 9

What are the common adverse effects of Cimetidine?

Answer 9

Headache

Dizziness

Question 10

What are the serious adverse effects of Cimetidine?

Answer 10

Food and drug allergies
Blood dyscrasias
Psychosis
Depression
Reversible impotence
Gynecomastia

Question 11

What substances does Cimetidine impair?

Answer 11

Caffeine

Cyclosporine