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Systemic Pharm > Antiemetics > Flashcards

Antiemetics Flashcards

1
Q

What are the 2 classes of anti-emetics?

A

H1 antagonists

D2 Antagonists

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2
Q

What is the MOA of Promethiazine?

A

Non-selective central and peripheral H1 antagonist

Some D2 antagonism

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3
Q

What are the serious side effects of Promethiazine?

A

Thrombocytopenia

Agranulocytosis

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4
Q

What is the black box for Promethiazine?

A

Respiratory depression

Gangrene

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5
Q

What happens when Promethiazine interacts with Macrolides, Azoles, or CAIs?

A

Prolonged QT segment

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6
Q

Promethiazine may impair the metabolism of which drug?

A

Beta-blockers

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7
Q

Which drugs interact with Promethiazine to cause an additive effect?

A

Anticholinergics
Sedating antihistamines
Olopatadine

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8
Q

There is a seizure warning when Promethiazine interacts with which substance?

A

Omega-6

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9
Q

What is the MOA of Chlorpromazine?

A

D2 antagonism

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10
Q

What are the common side effects of Chlorpromazine?

A

Blurred vision
Ocular pigmentation
Photosensitivity

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11
Q

What is the serious side effect of Chlorpromazine?

A

Blood dyscrasias

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12
Q

There is a seizure risk when Chlorpromazine interacts with what?

A

Omega-6

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13
Q

What type of drug is Ondansteron?

A

5-HT3 Antagonist

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14
Q

What is the indication for Ondansteron?

A

Chemo/e-ray nausea and vomiting

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15
Q

What are the serious adverse effects of Ondansteron?

A

SJS
TEN
Serotonin syndrome

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16
Q

What are the ocular side effects of Ondansteron?

A

Transient blindness

Oculogyric crisis

17
Q

Which drugs may interact with Ondansteron to cause a prolonged QT segment?

A

Macrolides
Azoles
CAIs

Systemic Pharm (15 decks)

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