ED

Question 1

What are the 3 drug classes used for ED?

Answer 1

Phosphodiesterase inhibitors
Alpha-2 agonists
Prostaglandin-E1 analogs

Question 2

What drug type is the first-line therapy for ED?

Answer 2

Phosphodiesterase inhibitors

Question 3

What are the 2 indications for Sildenafil Citrate?

Answer 3

ED

Pulmonary Arterial hypertension

Question 4

What is the action of Sildenafil Citrate?

Answer 4

Vasodilator

Question 5

What is the MOA of Sildenafil Citrate?

Answer 5

PDE-5 inhibitor, which sustains the vasodilatory effects of nitric oxide-dependent synthesis of cGMP

Question 6

What are the 4 common side effects of Sildenafil Citrate?

Answer 6

Headache
Abnormal vision
Dizziness
Nasal congestion

Question 7

What are the 6 serious adverse effects of Sildenafil Citrate?

Answer 7

MI
Stroke
Ventricular tachycardia
Hypotension/shock
Anemia
Leukopenia

Question 8

What are the 5 ocular side effects of Sildenafil Citrate?

Answer 8

Retinal hemorrhage
NAION
Vision loss
Elevated IOP
Cyanopsia

Question 9

What may occur if Sildenafil Citrate interacts with Azoles, Erythromycins, or Cyclosporine?

Answer 9

Reduced metabolism

Question 10

What may occur if Sildenafil Citrate interacts with alpha/beta blockers?

Answer 10

Additive effect

Question 11

Sildenafil Citrate may interact with which 3 drugs and cause reduced Sildenafil metabolism?

Answer 11

Azoles
Erythromycins
Cyclosporine

Question 12

Sildenafil Citrate may interact with which 2 drugs to cause an additive effect ?

Answer 12

Alpha-blockers

Beta-blockers