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Patho Pharm > HMG-CoA reductase inhibitors > Flashcards

HMG-CoA reductase inhibitors Flashcards

1
Q

Prototype

A

Atorvastatin

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2
Q

Route

A

PO

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3
Q

Pharmacokinetics

A

1st pass
CYP450

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4
Q

Metabolized

A

Liver

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5
Q

Excreted

A

Kidneys

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6
Q

Action

A

Inhibits HMG-CoA which is necessary for hepatic synthesis of cholesterol

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7
Q

Use

A

Hypercholesterolemia
Metabolic syndrome

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8
Q

Adverse effects

A

Nausea
Diarrhea
Constipation
Abdominal pain
headache
myopathy
liver problems

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9
Q

Interactions

A

Many
Increased effects with amiodarone, colchicine, azole antifungals, cyclosporine, verapamil, erythromycin
Grapefruit juice and vitamin B
Decreased effects with cholestyramine and colestipol

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10
Q

Nursing implications

A

Take in the evening
Liver studies (before you start, 12 weeks in, then periodically)

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Patho Pharm (22 decks)

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