ACE inhibitors Flashcards
1
Q
Prototype
A
Captopril
2
Q
Route
A
PO
3
Q
Pharmacokinteics
A
Well absorbed, very long half-life in people with renal impairment
4
Q
Metabolized
A
Kidney
5
Q
Excreted
A
Kidney
6
Q
Action
A
Blocks angiotensin 1 from converting to angiotensin 2 which causes vasoconstriction
Thus it leads to vasodilation and it also decreases aldosterone (salt and water leave the body)
7
Q
Use
A
HTN
Stops vascular remodeling
HF
Slow progression of albuminuria
8
Q
Adverse effects
A
Cough
Hypotension
hyperkalemia
9
Q
Interactions
A
Aliskiren, allopurinol
Amiloride and Spirolactone can cause hyperkalemia
Decreased absorption with iron
10
Q
Contraindications
A
Angioedema
pregnancy
11
Q
Nursing implications
A
Monitor BP
Cough (dry persistent cough)
Salt substitutes (hyperkalemia)
