HIV and AIDS

Question 1

Which type of HIV is most pathogenic?

Answer 1

HIV-1

Question 2

Zoonisis =

Answer 2

transmitted from animals - humans

Question 3

What type of virus is HIV?

Answer 3

retrovirus

Question 4

Genome of HIV

Answer 4

+ve RNA

Question 5

Does HIV have an envelope?

Answer 5

Yes

Question 6

How does HIV enter cell?

Answer 6

gp120 binds to cd4 and ccr5

Question 7

Acute HIV syndrome =

Answer 7

wide dessemination of virus. seeding of lyphoid organs

Question 8

What period comes after acute HIV syndrome?

Answer 8

clinical latency

Question 9

What originally drives down viral load?

Answer 9

CD8 cells

Question 10

On average, how long does it take to develop clinical immunodeficiency

Answer 10

6-8 years

Question 11

CD4 count for AIDs

Answer 11

<200

Question 12

AIDS associated infections (<200)

Answer 12

pneymocystis pneumonia
toxoplasmosis
oesophageal candida

Question 13

AIDS associated infections (<100)

Answer 13

mycobacterium avium intracellulare

cytomegalovirus

Question 14

Cancer associated with AIDS

Answer 14

Kaposi’s sarcoma

Question 15

What causes pneumocystis pneumonia

Answer 15

yeast-like fungus pneumocystis jirovecii

Question 16

What does toxoplasmosis effect?

Answer 16

CNS

Question 17

What does CMV lie latent in?

Answer 17

Retinal epithelium, causes CMV retinits/pizza pie retinitis

Question 18

Abacavir

Answer 18

NRTI

Question 19

Tenofovir

Answer 19

NRTI

Question 20

Lamivudine

Answer 20

NRTI

Question 21

Emtricitabine

Answer 21

NRTI

Question 22

What is in the name of NNRTIs?

Answer 22

vir in middle

Question 23

Nevirpine

Answer 23

NNRTI

Question 24

Etravirine

Answer 24

NNRTI

Question 25

Suffix of PIs

Answer 25

-navir (navir tease a pro)

Question 26

Atazanaivr

Answer 26

Protease inhibitor

Question 27

What is a boosting agent used with?

Answer 27

Protease inhibitors

Question 28

Ritonavir

Answer 28

Boosting agent

Question 29

Maraviroc

Answer 29

CCR5 inhibitor

Question 30

enfurvitide

Answer 30

fusion inhibitor

Question 31

What do integrase inhibitors have in the name

Answer 31

tegr in the middle

Question 32

Raltegravir

Answer 32

Integrase Inhibitor

Question 33

Elvitegravir

Answer 33

Integrase inhibitor

Question 34

When is ART recommended?

Answer 34

• pregnancy

- all infected

Question 35

Rules of ART

Answer 35

• need baseline CD4 and viral load
• Measure serology
• Resistance profile

Question 36

HLA-B5701 is a predictor of what?

Answer 36

Abacavir hypersensitivity

Question 37

Class used for post-exposure prophylaxis

Answer 37

NRTI

Question 38

Truvada is used for

Answer 38

PrEP

Question 39

Truvada is a mix of

Answer 39

tenofovir, emtricitabine

Question 40

U = U

Answer 40

undetectable = untransmissible