HIV and AIDS

Question 1

CD4 count is a good indicator of treatment efficacy for AIDS. True or false?

Answer 1

False

Question 2

Plasma viral RNA load is a good indicator for treatment efficacy. True or false?

Answer 2

True

Question 3

Upon diagnosis of HIV, treatment is started, regardless of CD4 count. True or false?

Answer 3

True

Question 4

A low dose of ritonavir is added to all protease inhibitors. Why?

Answer 4

Because it is a potent inhibitor of CYP3A4 so increases levels of protease inhibitor, so when coupled with another protease inhibitor, a lower dose of the PI can be used

Question 5

Protease inhibitors cross the BBB. True or false?

Answer 5

False

Question 6

For HIV, the initial therapy is 2 NRTIS plus one NNRTI, PI or integrase inhibitor. True or false?

Answer 6

True

Question 7

Adherence is very important with HIV therapy. True or false?

Answer 7

True

Question 8

Is post-exposure prophylaxis essential?

Answer 8

No - dependent on risk following sexual or occupational exposure