CF pseudomonas Flashcards
CF is a genetic disease. True or false?
True
CF is a result of a faulty ______ gene that can undergo multiple mutations.
CFTR
What are the symptoms of CF?
Chesty cough
Chest infection
Fatty diarrhoea
Poor weight gain
There is a high risk of which bacterial infection in the first two years of life?
Staph.aureus
It is important to isolate a child with a pseudomonal infection. True or false?
False - isolation has no impact
A pseudomonal colonisation can delay growth in children. True or false?
True
Is psuedomonas gram positive or negative?
Gram negative rod
Where is pseudomonas found?
Plants, water, soil and human and animal surfaces
What virulence factor aids psuedomonas in adhesion and host invasion?
Produces extracellular protease
Pseudomonas produces alginates. What is the benefit of this?
Aids biofilm formation
How can psuedomonal biofilms be transmitted?
Environmental sources e.g. sinks/drains
Invasive medical devices
What diagnosis tests can be run for pseudomonas?
Sputum Blood Discharge Stool Urine FBC
What medical conditions can be caused by pseudomonas?
Respiratory tract infections and sepsis
What is the pathophsiology of pseudomonas?
Colonises the mucus in the lower respiratory tract and grows to cover epithelium. This leads to biofilm proliferation and formation of scars and abscess
Which drugs are given as eradication therapy for psuedomonas?
Tobramycin/amikacin
Colistin/tobramycin
Ciprofloxacin
Azithromycin
