Antivirals

Question 1

Herpes virus and chickenpox are DNA viruses. True or false?

Answer 1

True

Question 2

If the RNA segment in a virus is used as mRNA directly, is it a positive or negative sense virus?

Answer 2

Positive

Question 3

If RNA segment in a virus is copied using a polymerase to give mRNA. Is it a positive or negative sense virus?

Answer 3

Negative

Question 4

Influenza and ebola are negative sense viruses. True or false?

Answer 4

True

Question 5

Is hep B a DNA or RNA virus?

Answer 5

DNA but with a retroviral phase

Question 6

Is polio virus a positive or negative sense virus?

Answer 6

Positive

Question 7

Influenza B is exclusive to humans, seals and ferrets. True or false?

Answer 7

True

Question 8

Amantidine and Rimantidine are antivirals that are no longer recommended. What are the recommended ones?

Answer 8

Oseltamivir

Zanamivir

Question 9

Amantidine and rimantidine are acids. True or false?

Answer 9

False - tricyclic amines

Question 10

What is the natural substrate of neuraminidase in influenza?

Answer 10

Sialic acid

Question 11

Zanamivir and oseltamivir are transition state inhibitors. True or false?

Answer 11

True

Question 12

Zanamivir is very polar with poor biolavailability. True or false?

Answer 12

True

Question 13

How is zanamivir administered?

Answer 13

Inhalation

Question 14

Oseltamivir is an ester prodrug. True or false?

Answer 14

True - converted into free COOH in the GIT

Question 15

Human rhinovirus is a negative sense virus. True or false?

Answer 15

False - positive sense

Question 16

Acyclovir is only used in HSV 1 and 2, not chickenpox. True or false?

Answer 16

False

Question 17

Acyclovir is a purine analogue. True or false?

Answer 17

True

Question 18

cellular thymidine kinase has a lower affinity for acyclovir than viral thymidine kinase and so acyclovir doesn’t affect normal cells. True or false?

Answer 18

True

Question 19

Acyclovir is used topically or injected. True or false?

Answer 19

True

Question 20

Ganciclovir is less toxic than acyclovir. True or false?

Answer 20

False

Question 21

Peniciclovir is an isostere of which antiviral?

Answer 21

Ganciclovir

Question 22

Famiciclovir is a prodrug of which antiviral?

Answer 22

Peniciclovir

Question 23

Valaciclovir is a prodrug. True or false?

Answer 23

True - valine ester of acyclovir

Question 24

Viruses that lack thymidine kinase are resistant to acyclovir. True or false?

Answer 24

True

Question 25

There is no known cure for HIV. True or false?

Answer 25

True

Question 26

What are the three groups of anti-HIV drugs?

Answer 26

NRTIs
NNRTIs
Protease inhibitors

Question 27

How do NRTIs work?

Answer 27

AZT is phosphorylated by host thymidine kinase into triphosphate AZT, which is an inhibitor or reverse transcriptase

Question 28

Didanosine, emtricitabine and lamivudine are examples of which type of anti-HIV drugs?

Answer 28

NRTIs

Question 29

How do protease inhibitors work for HIV treatment?

Answer 29

They act as transition state inhibitors

Question 30

Saquinivir, Ritonavir and Indinavir are examples of which group of anti-HIV drugs?

Answer 30

Protease inhibitors

Question 31

How do NNRTIs work?

Answer 31

They act remotely at the active site and don’t require phosphorylation.

Question 32

Neviripine, efavirenz and delavirdine are examples of which group of anti-HIV drugs?

Answer 32

NNRTIs

Question 33

How does enfuviritde work in treating HIV?

Answer 33

It inhibits the fusion of HIV virus to the host