Histology Of The Skin And Breast Flashcards
What are the main functions of skin
Provides a barrier to infection
Waterproof
Thermoregulation
Protect against trauma
Protect against uv-light
Vitamin D synthesis
Sensation
What is the epidermis of the skin made up of
Type IV collagen
What is not visible with H&E in the epidermis
The basement membrane
What does the stratum basale sit on
The basement membrane
What is the stratum basale made up of
Basal epithelial cells (stem cells)
Melanocytes
Where are melanocytes present
In the basal layer of the epidermis
What is the role of the melanocytes
They synthesis melanin and transfer it to the surrounding keratinocytes in melanosomes in response to MSH and ACTH stimulation
What does melanin absorb
It absorbs ultraviolet light which protects us from non-ionising radiation damage
What cells are found in the stratum spinosum
Keratinocytes
Langerhans cells
Merkel cells
What makes up the stratum granulosum
Flattened squares
Eosinophilic cytoplasm
Haematoxophilic kerato-hyaline granules
What makes up the stratum corneum
It is acellular
Made up of plates of keratin
What are epidermal adnexae
Downgrowths of the epidermis into the dermis
What do the downgrowths in the dermis become
Hair follicles
Sebaceous glands
Eccrine sweat glands
Apocrine sweat glands
What is the function of a sebaceous gland
To produce sebaceous secretions which lubricate and waterproof hairs
Where will you find sebaceous glands
They are found in downgrowths of the dermis accompanying hair follicles
Where will you find apocrine glands
Accompanying hair follicles
What are the apocrine glands made up of
Simple coiled tubular gland with eosinophilic cytoplasm
What is the function of eccrine glands
Secrete water secretions
Where can eccrine glands be found
Everywhere
What is the dermo-epidermal junction
A junction between the epidermis and dermis, this is not flat but is ridged due to the epidermis protruding downwards into the dermis
What layer make up the dermis
Papillary dermis
Reticular dermis
Subcutis
What is the dermis comprised of
Irregular loose connective tissue
Fibroblasts
Collagen
Glycosaminoglycan matrix
Blood vessels
Lymphatics
Nerves
Sensory cells
Scattered inflammatory cells
What are sensory structures in the dermis
Meissners corpuscle
Pacinian corpuscle
What are meissners corpuscles
Encapsulated unmyelinated nerve endings found In the dermis
What is a Pacinian corpuscle
It is a large encapsulated sensory receptor in the dermis which deals with vibration and tickle
What is the subcutis comprised of
Adipose tissue
Firovascular septa
Insulation
Shock-absorber
Food store
When does breast tissue become present and when does it develop
It id present from birth but only begins to develop at puberty
What makes up the tissue of the breast
Myoepithelial system of ducts and lobules set in a fibroadipose connective tissue
Where doe all ducts of the breast empty
At the nipple
What are the 2 layers of cells which line the ducts and lobules
Outer myoepithelium
Inner columnar epithelium
What is the primary function of the breast
For lactation
What is this showing
The epidermis
What layer is the arrow showing
The stratum basale
What layer is the arrow showing
The stratum spinosum
What layer is the arrow pointing to
The stratum granulosum
What layer is the arrow pointing to
The stratum corneum
What is this showing
The epidermal adnexae
What gland can you see in this
Sebaceous glands
What gland can you see in this
Apocrine gland
What gland can you see here
Eccrine glands
What is this showing
The demo-epidermal junction
What is this showing in general and what are the arrows showing
The dermis
First arrow = papillary dermis
Second arrow = reticular dermis
Third arrow = subcutis
What structure is this
Pacinian corpuscle
What is this showing
The subcutis
What is this showing
Terminal duct lobular units
What is this showing in general and what are the arrows pointing to
This is lactation tissue in the breast
The first arrow = duct
The second arrow = inner layer of secretory cells
What is this showing in general and what are the arrows pointing to
This is lactation tissue in the breast
The first arrow = duct
The second arrow = inner layer of secretory cells
