Histology of the Digestive System Flashcards
What are the layers of the wall of the alimentary canal?
from lumen, outward
Mucosa
Submucosa
Muscularis externa
Serosa or Adventitia
What are the layers of the Mucosa of the Alimentary canal?
Lining epithelium
Lamina Propria
Muscularis mucosae
Lining Epithelium
Superficial layer of the mucosa of the Alimentary canal
Where would the lining epithelium of mucosa be nonkeratinized stratified squamous epithelium?
Regions that need protection:
Mouth, Pharynx, Esophagus, Anus
Where would the lining epithelium of the muscoa be simple columnar epithelium?
Regions of absorption:
Stomach, Small intestines, Large intestines
Lots of tight junctions here
What layer do things need to cross to be “in the body”
Lining epithelium of the mucosa
Lamina propria
Middle layer of mucosa
Loose areolar Connective tissue
Lots of lymphatics here and some glands
Muscularis mucosa
Smooth muscle tissue layer of the mucosa
Submucosa
Dense irregular connective tissue
Binds submucosa for the muscularis externa
Meissner’s Plexus
Lots of myelinated nerve endings in the submucosa
What are the layers of the Muscularis externa
Inner circular layer
Nervouse tissue
Outer longitudinal layer
Inner circular layer of Muscularis externa
Smooth muscle in Muscularis externa
Thickened in sphincters and valves
Contract to close down lumen, and lengthen the GI tract
Nervous tissue of Muscularis externa
In between muscle layers
Location of Mysenteric nerve plexus
Outer layer of Muscularis externa
Smooth muscle
Contracts to dilate the lumen and shorten theGI tract
Serosa and Adventitia
Loose areolar connective tissue
Serosa has a mesothelium on the very outside
Esophagus Mucosa
Nonkeratinized stratified squamous epithelium
Esophageal cardiac glands in lamina propria
Esophagus Submucosa
Dense irregular CT
Connect muscosa to muscularis externa
Contains esophageal glands
Esophagus Muscularis Externa
Skeletal muscle proximally and smooth muscle distally
Moves bolus through GI tract
Esophagus Serosa/Adventitia
Adventitia superior to diaphragm
Serosa inferior to the diaphragm
Esophagus Glands
Esophageal glands proper
Esophageal Cardiac glands
Esophageal glands proper
In the submucosa
Esophageal cardiac glands
In the lamina propria
Subdivisions of the Stomach
Cardia
Fundis
Body
Pylorus
Cardia of the stomach contents
Cardiac glands - primarily mucos
Fundus of the stomach contents
Gastric glands - contain cells that secrete HCl and pepsin
Body of the stomach contents
Gastric glands - contain cells that secrete HCl and pepsin
Mucosa of the stomach
Protect other layers from food and gastric juices
Simple Columnar epithelium
Gastric pits
Gastric pits
Lead to simple branched tubular glands
Muscularis externa of the Stomach
The inner circular layer is now middle
There are inner oblique muscles
Small intestines Sections
Duodenum
Jejunum
Ileum
What is the length of the small intestines in living patients? Cadavers?
Living - 10 ft
Cadaver - 21 ft
Plica circularis of the small intestines
Submocosa core
Circular folds
Villi of the small intestines
Finger-like projections of mucosa
Microvilli of the small intestines
Protection of apical membrane of intestinal absorptive cells
Striated border
Mucosa of the small intestines
Simple columnar epithelium
Contain enterocytes
Contain goblet cells
Enterocytes
Absorptive cells
Tall columnar cells with basal nuclei
Have microvilli at the surface so the can also be secretory
Goblet cells
Secrete mucus
Few proximally and increase the farther you go
What are mucosa modifications of the small intestines
Enterocytes
Goblet cells
Crypts of Lieberkun
Crypts of Lieberkun
Contiains Tubular glands, Paneth cells, Enteroendocrine cells
Stem cells
Paneth cells
At bases of Crypts of Lieberkun in small intestines
Balance normal bacterial flora
Secrete lysozyme, which is important for digestion of bacterial cell wall
Enteroendocrine cells
Secrete hormones in the small intestines
Where are Brunner’s glands?
Only in the duodenum - in the submucosa
Brunner’s glands
Produce alkaline mucous
Neutralize pH, since we get low pH stuff of the stomach
Only in the duodenum
M cells
Specialized epithelial in ileum overlying Peyer’s patches
They sample things before shipping them off to immune cells
What are tenaie coli?
Muscles that go longitudinally down the large intestine
Part of the muscularis externa
Haustra
Bulbous bodies as part of the colon
Large intestines epithelum
Simple columnar epithelium
Lamina propria of the large intestines
Layer of mucosa
Contains lymphoid cells and lymphoid tissues
What are the divisions of the Pancreas?
Head
Body
Tail
Pancreas functions
98-99% = exocrine gland (compound acinar) 1-2% = endocrine gland (Islets of Langerhans)
What are the 2 blood sources to the liver?
Hepatic artery (oxygenated blood) Hepatic Portal vein (deoxigenated blood with newly absorbed nutrients, drugs, microbes from GI)
What is the blood drainage of the liver?
Hepatic a./Hep Portal vein to Liver sinusoids to Central Canal to Hepatic vein to IVC
Liver sinusoids
Where oxygen, most nutruents and toxic substances are taken up by hepatocytes
Also where hepatocytes products and stored nutrients are secreted back to the blood
Hepatic lobule
Functional and structural unit of the liver
Six-sided structure with Hepatocytes surrounding a Central Vein
Kupfer cells
Largest cell lining liver sinusoids
Stellate macrophages
Phagocytotic
Brakdown old or damaged RBCs
Gallbladder
Secretes bile