Herpies Viruses Flashcards
What type of VIrus are Herpes Simple Virus Type 1 and Type 2 (HSV-1 and HSV-2)
Alphaherpesciridae (like varicella Zoster virus)
Host range of Alphaherpesvirus
Variable host range
Length of reproduction cycle of Alphaherpesvirus
Short
speed of culture spread of Alphaherpesvirus
Rapid Spread
Descruction efficiency of infected cells by Alphaherpesvirus
Efficient destruction (cyototix-can lyse cells)
where can Alphaherpesvirus establish latency
In sensory ganglia
Herpies virus type I infects where
waste up
Herpies virus Type II infects where
waste down
how does HSV-1 infect
oral-oral, oral-genital
amount of adults that are seropositive for HSV-1
nearly 2/3
How does HSV-2 infect
Primarily genital-genital, also oral-genital possible
prevealent with sexual activity
amount of adults with HSV-2
1/5 of adults are infected
where does HSV-1 and HSV-2 infected
Epithelial cells in the skin or mucosa (mucosa more susceptible)
Incubation of HSV-1 and 2
2-14 days, but typically 4-5 days
Symptoms of HSV 1 and 2
Flu-like, includes localized lesions (virus spreads to neighboring cells primarily)
who shows symptoms of HSV-1 and 2
1/3
can asymptomatic people transmit HSV-1 and 2
yes
how long does the Symptoms of HSV 1 and 2 last
8-12 days
Latency of Alphaherpesvirus occures where
In stationary cells
peripheral ganglia common site of latent infections
what occures in latency of Alphaherpesvirus
Genome circularizes and stays as an episome in the nucleus
what triggers latent Alphaherpesvirus
Sunburn, systemic infection, immune impairment, stresss
What immune response is used to fight Alphaherpesvirus
Cell mediated immune response required
can people who cant produce antibodies handle herpesvirus infections
YEs
what detects Alphaherpesvirus
T lymphocytes detect antigens presented by MHC I or II proteins
how does Alphaherpesvirus modulate the immune response to evade it
Viral proteins bind to Antibodies and complement proteins that counter effects of interferon
as people age are they more likely or less likely to be serum possitive for Alphaherpesvirus
more likely
Prevention of Alphaherpesvirus
Avoid contact (kissing, sex) during active herpes recurrence
Treating Alphaherpesvirus
Acyclovir can be used to limit virus replication, but will not eliminate latent infectinos
Host range of Betaherpesvirus
restricted
reproduction time of Betaherpesvirus
Long
profession in cell culture of Betaherpesvirus
Slow Progresion in cell culture
what does Betaherpesvirus do to infected cells
Cytomeglia (enlargement of infected cells)
what kind of culture does Betaherpesvirus lead to
Carrier cultures- cell line that keeps producing the virus without injury to cell
Where does Betaherpesvirus create a latent infection
In a variety of tissures
Cytomegalovirus is a member of what
Betaherpesvirus
Host range of Gammaherpesvirus
Restricted host range
What does Gammaherpesvirus target
T and B lymphocytes
what type of infection does Gammaherpesvirus create
Lytic infections
where does Gammaherpesvirus create latency
In lymphoid tissues