Herpesvirus and Papillomavirus Flashcards
what is the family, genome, and virion of both Type 1 and Type 2 Herpes Simplex
family - alphaherpesvirus
genome - dsDNA
virion - enveloped
what is the difference b/w alphaherpesvirus and beteherpesvirus with regards to length of reproduction cycles
alphaherpesvirus - short reproduction cycles allowing for rapid spread in culture
betaherpesvirus - long reproduction cycles
what is the difference b/w HSV-1 and HSV-2 w/regards to where they affect the human
HSV-1 above the waist
HSV-2 below the waist
what type of herpes virus is unique in that only 1/3 of infected people show symptoms ? Why is this ?
Alphaherpesvirus, b/c many people’s immune systems can handle the infection w/o showing any symptoms
what is the difference b/w alphaherpesvirus and beta/gammaherpesvirus with regards to the host range it can affect
alphaherpesvirus - large host range
beta/gammaherpesvirus - restricted host range
what drug should be used to treat alphaherpesvirus, but will NOT eliminate latent infections
acylovir
what is the common name of the virus from the betaherpesvirus family
cytomegalovirus (CMV)
what is the common name of the virus from the gammaherpesvirus family
Epstein-Barr virus (EBV)
what are the 2 EBV associated carcinomas ?
- Burketts lymphoma
- Hodgkins lymphoma
Betaherpesvirus or CMV have the ability to compromise what host immune functions ?
- Block cell death (inhibit apoptosis)
- decrease NK cell activity
- decrease antigen presentation
Alphaherpesvirus or HSV-1 and HSV-2 have the ability to compromise what immune function ?
- Block cell death (inhibit apoptosis)
- decrease NK cell activity
- decrease antigen presentation
gammaherpesvirus or EBV have the ability to compromise what immune function ?
- Block cell death (inhibit apoptosis)
- decrease antigen presentation
what specific herpes virus persists in hematopoeitic progenitor cells, causing a chronic persistence (not latency)
CMV
where do EBV genome cells persist ?
memory B cells
Of all types of herpesvirus, which 2 are known to be self-limiting or not that severe
beta/gammaherpesviruses
-CMV and EBV
what is the family, genome, and virion of human papillomavirus
family - papilloviridae
genome - dsDNA
virion - nonenveloped
Human papillomavirus gains access through the _____, and needs active _____ cells in the host in order to replicate
skin,
basal lamina
how can the human papillomavirus be transmitted
skin to skin contact and fomites
what are the generic symptoms for all strains of the human papillomavirus
warts
if the human papillomavirus was to become oncogenic, what pathways would it have BLOCK to keep cell proliferation constant
-pRb pathway via E7
p53 pathway via E6
oncogenesis of human papillomavirus results in what type of cancer
cervical canver
most treatments for human papillomavirus are ablative, what does this mean
-burned off, cut off, lasered off
what is the name of the vaccine for Human papillomavirus
gardasil (Merck)
