Herpesvirus and Papillomavirus Flashcards

1
Q

what is the family, genome, and virion of both Type 1 and Type 2 Herpes Simplex

A

family - alphaherpesvirus
genome - dsDNA
virion - enveloped

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2
Q

what is the difference b/w alphaherpesvirus and beteherpesvirus with regards to length of reproduction cycles

A

alphaherpesvirus - short reproduction cycles allowing for rapid spread in culture
betaherpesvirus - long reproduction cycles

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3
Q

what is the difference b/w HSV-1 and HSV-2 w/regards to where they affect the human

A

HSV-1 above the waist

HSV-2 below the waist

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4
Q

what type of herpes virus is unique in that only 1/3 of infected people show symptoms ? Why is this ?

A

Alphaherpesvirus, b/c many people’s immune systems can handle the infection w/o showing any symptoms

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5
Q

what is the difference b/w alphaherpesvirus and beta/gammaherpesvirus with regards to the host range it can affect

A

alphaherpesvirus - large host range

beta/gammaherpesvirus - restricted host range

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6
Q

what drug should be used to treat alphaherpesvirus, but will NOT eliminate latent infections

A

acylovir

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7
Q

what is the common name of the virus from the betaherpesvirus family

A

cytomegalovirus (CMV)

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8
Q

what is the common name of the virus from the gammaherpesvirus family

A

Epstein-Barr virus (EBV)

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9
Q

what are the 2 EBV associated carcinomas ?

A
  • Burketts lymphoma

- Hodgkins lymphoma

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10
Q

Betaherpesvirus or CMV have the ability to compromise what host immune functions ?

A
  • Block cell death (inhibit apoptosis)
  • decrease NK cell activity
  • decrease antigen presentation
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11
Q

Alphaherpesvirus or HSV-1 and HSV-2 have the ability to compromise what immune function ?

A
  • Block cell death (inhibit apoptosis)
  • decrease NK cell activity
  • decrease antigen presentation
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12
Q

gammaherpesvirus or EBV have the ability to compromise what immune function ?

A
  • Block cell death (inhibit apoptosis)

- decrease antigen presentation

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13
Q

what specific herpes virus persists in hematopoeitic progenitor cells, causing a chronic persistence (not latency)

A

CMV

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14
Q

where do EBV genome cells persist ?

A

memory B cells

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15
Q

Of all types of herpesvirus, which 2 are known to be self-limiting or not that severe

A

beta/gammaherpesviruses

-CMV and EBV

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16
Q

what is the family, genome, and virion of human papillomavirus

A

family - papilloviridae
genome - dsDNA
virion - nonenveloped

17
Q

Human papillomavirus gains access through the _____, and needs active _____ cells in the host in order to replicate

A

skin,

basal lamina

18
Q

how can the human papillomavirus be transmitted

A

skin to skin contact and fomites

19
Q

what are the generic symptoms for all strains of the human papillomavirus

A

warts

20
Q

if the human papillomavirus was to become oncogenic, what pathways would it have BLOCK to keep cell proliferation constant

A

-pRb pathway via E7

p53 pathway via E6

21
Q

oncogenesis of human papillomavirus results in what type of cancer

A

cervical canver

22
Q

most treatments for human papillomavirus are ablative, what does this mean

A

-burned off, cut off, lasered off

23
Q

what is the name of the vaccine for Human papillomavirus

A

gardasil (Merck)