Herpes II

Question 1

What is the primary infection of EBV?

Answer 1

• Asymptomatic Infection

- Infectious Mononucleosis

Question 2

What cancer is EBV associated with?

Answer 2

• Burkitt’s Lymphoma

- Nasopharyngeal Carcinoma

Question 3

What is the pathogenesis of EBV?

Answer 3

Virus in saliva infects epithelia and spreads to B cells in lymphatics which promotes B cell growth

Question 4

What cells are required to control EBV infection?

Answer 4

T cells - they kill and control the B cell outgrowth

Question 5

What is used for EBV detection?

Answer 5

• Monospot test

- IgM and IgG profile to EBV antigens

Question 6

Is there treatment for EBV?

Answer 6

No

Question 7

What is the predominant response to CMV infection?

Answer 7

Asymptomatic Infection

Question 8

When can CMV infection be serious?

Answer 8

Fetal/Neonatal Infection

Question 9

What causes mononucleosis and is heterophile Ab negative?

Answer 9

CMV

Question 10

What can be used to identify CMV?

Answer 10

PCR, Serology, Histology

Question 11

What are the treatments for CMV?

Answer 11

• Ganciclovir

- Letermovir

Question 12

What is the problem with ganciclovir?

Answer 12

Bone marrow toxicity

Question 13

Letermovir MOA

Answer 13

Inhibits CMV terminase complex

Question 14

Roseola

Answer 14

• Rapid onset of high fever

- Generalized rash

Question 15

What is the viral cause of roseola?

Answer 15

Caused by HHV6 and HHV7

Question 16

How is HHV6 and HHV7 diagnosed?

Answer 16

Clinical presentation

Question 17

What disease does HHV8 cause?

Answer 17

Kaposi’s sarcoma

Question 18

What is required for HHV8 to be serious?

Answer 18

Immunocompromised state

Question 19

Kaposi’s Sarcoma

Answer 19

Red raised lesion with spindle-shaped tumor cells and inflammatory infiltrate

Question 20

How is HHV8 spread?

Answer 20

Sexual contact