Acute Inflammation Flashcards
What is transudate?
ECF with low levels of protein
What is exudate?
ECF with high levels of protein
What is the activator of the inflammatory response?
DAMPs and PAMPs activate TLRs on monocytes which leads to the formation of the inflammosome
What is the inflammosome?
It is a complex that activates Caspase 1 and activates IL-1 that leads into the inflammatory cytokines
What is the function of the cytokine release from the monocytes?
- Recruit leukocytes
- Vasodilation
- Increased permeability
What is margination?
Neutrophils migrate to the edges of the vessels and will adhere and roll along it
What is the function of NADPH oxidase?
Used to destroy foreign organisms with oxidative burst
What is “left shift?”
It is the release of immature neutrophils with a C-shaped nucleus
What are NETs?
Neutrophil extracellular traps that act as a chromatin spray to the outside of the cell to trap bacteria and fungi
How does the inflammatory response end?
TGF-B and IL-10 become dominant and lead to suppression
What is serous inflammation?
Protein poor transudate from capillary to a space‐peritonel, pericardial or pleural. Known clinically as a transudate
What is fibrinous inflammation?
Fluid with larger molecules dominated by fibrinogen which converts to fibrin and potential scarring
What is suppurative inflammation?
Protein rich fluid with inflammatory cell, alive and dead necrotic debris.
Known clinically when in a body space as an exudate
What is ulcerative inflammation?
Underlying inflammation cause excavation of a mucosal or skin surface
