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Infection > Hepatitis > Flashcards

Hepatitis Flashcards

1
Q

What is hepatitis?

A

Inflammation of the liver

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2
Q

What are hepatitis viruses?

A

Viruses with replication specifically in hepatocytes which destroy hepatocytes

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3
Q

How many hepatitis viruses are there?

A

5

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4
Q

What are the hepatitis viruses?

A 
Hep A
Hep B
Hep C
Hep D
Hep E
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5
Q

Which can cause chronic illnesses?

A

Hep B
Hep C

Hep D (with hep B)

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6
Q

What is the structure of hep A?

A

Single stranded positive strand non enveloped icosahedral RNA virus

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7
Q

What is the structure of hep B?

A

Double stranded enveloped DNA virus

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8
Q

What is the structure of hep C?

A

Single stranded positive strand enveloped icosahedral RNA virus

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9
Q

What is the structure of hep D?

A

Spherical enveloped virusoid

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10
Q

What is the structure of hep E?

A

Single stranded positive strand non enveloped icosahedral RNA virus

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11
Q

How is hep B transmitted?

A

Vertical transmission
Sexual contact
Blood exposure

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12
Q

What are the symptoms of acute hep B?

A 
Jaundice 
Fatigue 
Abdominal pain 
Anorexia 
N+V
Arthralgia
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13
Q

What is the incubation period for hep B?

A

6 weeks - 6 months

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14
Q

What is the serology of hep B?

A
  1. surface antigen HBsAg first
  2. followed by e-antigen HBeAg
  3. core antibody (IgM) appears
  4. followed by e-antibody HBeAb
  5. Surface antibody appears HBsAb
  6. Core antibody IgG persists for life
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15
Q

What is the definition of a chronic hep B infection?

A

Persistence of HBsAg after 6 months

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16
Q

Is there a cure for hep B?

A

No

17
Q

How is hep B managed?

A

Life long antiretrovirals to suppress viral replication

18
Q

Is there a vaccination for hep B?

A

Yes

- produces surface antigen response

19
Q

What is the status if:
HBsAg +
HBcAb IgM +
HbsAb +/-

A

Acute infection

20
Q

What is the status if:
HBsAg -
HBcAb IgG +
HbsAb +

A

Past infection - cleared

21
Q

What is the status if:
HBsAg +
HBcAb IgG +
HbsAb -

A

Chronic infection

22
Q

What is the status if:
HBsAg -
HBcAb -
HbsAb +

A

Never infected but vaccinated

23
Q

How is hep C transmitted?

A

Drug use
Sexual contact
Needlestick injury

24
Q

How many of those infected with hep C will become chronically infected?

A

80%

25
Q

What are the symptoms of a hep c infection?

A

80% - asymptomatic

20%

  • fatigue
  • RUQ pain
  • nausea
26
Q

What is the serology of hep C?

A

Anti-hep C antibody only - persists life long

27
Q

Is there a cure for hep C?

A

Yes

8-12 weeks of antiviral drugs

28
Q

Is there a vaccine for hep C?

A

No

Infection (13 decks)

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