Hemostatic Disorders Flashcards
coagulation disorders are either
congenital or acquired
which congenital disorders deal with issues with primary hemostasis
von Willebrand
Glanzmann’s Thrombasthenia
Storage Pool Disease
which congenital disorders deal with issues with secondary hemostasis
Hemophilia A and B
type 1 von Willebrand Disease
low levels of circulating vWF with normal structure
autosomal dominant with incomplete penetrance
type 2 von Willebrand Disease
low levels of circulating vWF with abnormal structure
dominant inheritance
most severe bleeding
type 3 von Willebrand Disease
near absent vWF
autosomal recessive
most severe bleeding
what is the deficit in Glansmann’s Thrombasthenia
platelet fibrinogen receptor
GPIIb/GPIIIa
what is the result of Glansmann’s Thrombasthenia
platelet aggregation defect and severe bleeding
what is the deficit in Inherited Platelet Storage Pool Disease
ADP granules within platelets
what is the result of the deficit in Inherited Platelet Storage Pool Disease
moderate to severe bleeding tendency
which coagulation factor is deficient in Hemophilia A
Factor VIII
which tests would you expect to be prolonged in an animal with Hemophilia A
ACT
PTT/aPTT
which coagulation factor is deficient in Hemophilia B
Factor IX
which coagulation tests would you expect to be prolonged in an animal with Hemophilia B
ACT
PTT/aPTT
which gender is most likely to be clinical with Hemophilia A
males
