Hemoglobin affinity

Question 1

Decreased PCO2: increased or decreased affinity for O2?

Answer 1

Increased

Question 2

Increased affinity: right or left shift of the curve?

Answer 2

Left

Question 3

Decreased pH: increased or decreased affinity for O2?

Answer 3

Decreased

Question 4

Acidosis: increased or decreased affinity for O2?

Answer 4

Decreased

Question 5

Fetal hemoglobin: increased or decreased affinity for O2?

Answer 5

Increased

Question 6

Decreased affinity: right or left shift of the curve?

Answer 6

Right

Question 7

Bohr effect: right or left shift of the curve?

Answer 7

Right

Question 8

Decreased temperature: increased or decreased affinity for O2?

Answer 8

Increased

Question 9

Increased pH: increased or decreased affinity for O2?

Answer 9

Increased

Question 10

Increased PCO2: increased or decreased affinity for O2?

Answer 10

Decreased

Question 11

High 2,3-BPG (produce in red blood cells during glycolysis): increased or decreased affinity for O2?

Answer 11

Decreased

Question 12

Alkalosis: increased or decreased affinity for O2?

Answer 12

Increased

Question 13

Increased temperature: increased or decreased affinity for O2?

Answer 13

Decreased

Question 14

Carbon monoxide poisoning: increased or decreased affinity for O2?

Answer 14

Increased

Question 15

Adaptation to high altitudes (low pO2): 6 steps in order?

Answer 15

1. increased respiration
2. increased O2 affinity for hemoglobin (initially)
3. increased rate of glycolysis
4. increased 2,3-BPG in red blood cells over a 12-24 hour period
5. normalized O2 affinity restored by increased 2,3-BPG
6. increased levels of hemoglobin, after days or weeks

Question 16

PO2 = 100 mmHg = ? hemoglobin saturation → what tissue?

Answer 16

100%

Lungs

Question 17

PO2 = 40 mmHg = ? hemoglobin saturation → what tissue?

Answer 17

80%

tissues during rest

Question 18

PO2 = 20 mmHg = ? hemoglobin saturation → what tissue?

Answer 18

30%

tissues during exercise