Heme Onc Flashcards
What is entero hepatic bilirubin circulation and what enzyme does it
Bilirubin conjugated in lived and secreted into bike gets de conjugated in gut and resorbed into blood
Beta glucoronidase
Thrombocytopenia incidence in less than 800 grammars
85 percent
Critical threshold for oxygen delivery in healthy adults below which tissue hypoxia happens (ml per kilo per minute)
7.3
How does the K B test distinguish fetal from maternal cells ?
Fetal is resistant to acid elusion
What percentage of TMD will present with hepatomegaly ?
50 percent
Thrombopoetin (Tpo) levels in SGA neonate versus adult
Lower
What type of cells is a hepatic hemangioma made of ?
Mesenchymal cells
What Is Leukocyte reduction of blood for
decrease risk of CMV transmission
Up to x percent of China and SE Asia are alpha thal carriers
40 percent
Percent of newborns store of Iron accrued during third trimester
80 percent
Severe neonatal hyperbili with initial negative G6PD then deficient months later - why?
Initial hemolysis leading to more younger RBC
Compared to epo, darby has half life that is x longer than epo
13 fold
Peak Bili occurs at what hours of life ?
96 hours
Only PO metaloporphyrin (treats hyperbili)
Chromium
What thalassemia is Hb Constant Spring clinically similar to ?
Beta thal major and may require transfusions during infancy
Most common metabolic anomaly seen with polycythemia (65)?
Hypoglycemia
AFP is elevated in x percent of patients with hepatoblastoma and low levels are a marker for x prognosis
90 percent
Poor
Thrombocytopenia with absent radius (TAR) syndrome is different from fanconi in what regard ?
Has thumbs !
Threshold for total bilirubin albumin ratio in term babies with physiologic jaundice
0.8
Heme oxygenase degrades heme into bili- HO1 is where and HO2 is where ?
Spleen is the primary breakdown place
Brain
Most common kidney tumor
Congenital mesoblastic nephroma
Why are plasma concentrations of epo in pretermers lower than those in older children ?
Increased metabolic clearance
For carriers of alpha globin gene, Asians tend to have x while blacks x
Cis
Trans
Dose of epo for EPBW
500-1000
Percentage of people with kernixterus who are dx with g6pd
20 percent
Sacrococcygeal tumors are highly x and can lead to high output x
Vascular
Cardiac failure
Sickle cell is caused by homozygous x or co inheritance with x
HbSS
HbS with another beta globin variant
TMD occurs in up to x percent of people with DS
Ten
The earliest fraction of Bili is derived from x
Turnover of heme precursors
Equation to calculate volume of rbc needed to get a desired crit
Weight times 1.6 * (desired crit minus actual crit )
CRIT nadir for healthy term babies is when
8 weeks
