Heme Onc

Question 1

What is entero hepatic bilirubin circulation and what enzyme does it

Answer 1

Bilirubin conjugated in lived and secreted into bike gets de conjugated in gut and resorbed into blood
Beta glucoronidase

Question 2

Thrombocytopenia incidence in less than 800 grammars

Answer 2

85 percent

Question 3

Critical threshold for oxygen delivery in healthy adults below which tissue hypoxia happens (ml per kilo per minute)

Answer 3

7.3

Question 4

How does the K B test distinguish fetal from maternal cells ?

Answer 4

Fetal is resistant to acid elusion

Question 5

What percentage of TMD will present with hepatomegaly ?

Answer 5

50 percent

Question 6

Thrombopoetin (Tpo) levels in SGA neonate versus adult

Answer 6

Lower

Question 7

What type of cells is a hepatic hemangioma made of ?

Answer 7

Mesenchymal cells

Question 8

What Is Leukocyte reduction of blood for

Answer 8

decrease risk of CMV transmission

Question 9

Up to x percent of China and SE Asia are alpha thal carriers

Answer 9

40 percent

Question 10

Percent of newborns store of Iron accrued during third trimester

Answer 10

80 percent

Question 11

Severe neonatal hyperbili with initial negative G6PD then deficient months later - why?

Answer 11

Initial hemolysis leading to more younger RBC

Question 12

Compared to epo, darby has half life that is x longer than epo

Answer 12

13 fold

Question 13

Peak Bili occurs at what hours of life ?

Answer 13

96 hours

Question 14

Only PO metaloporphyrin (treats hyperbili)

Answer 14

Chromium

Question 15

What thalassemia is Hb Constant Spring clinically similar to ?

Answer 15

Beta thal major and may require transfusions during infancy

Question 16

Most common metabolic anomaly seen with polycythemia (65)?

Answer 16

Hypoglycemia

Question 17

AFP is elevated in x percent of patients with hepatoblastoma and low levels are a marker for x prognosis

Answer 17

90 percent
Poor

Question 18

Thrombocytopenia with absent radius (TAR) syndrome is different from fanconi in what regard ?

Answer 18

Has thumbs !

Question 19

Threshold for total bilirubin albumin ratio in term babies with physiologic jaundice

Answer 19

0.8

Question 20

Heme oxygenase degrades heme into bili- HO1 is where and HO2 is where ?

Answer 20

Spleen is the primary breakdown place
Brain

Question 21

Most common kidney tumor

Answer 21

Congenital mesoblastic nephroma

Question 22

Why are plasma concentrations of epo in pretermers lower than those in older children ?

Answer 22

Increased metabolic clearance

Question 23

For carriers of alpha globin gene, Asians tend to have x while blacks x

Answer 23

Cis
Trans

Question 24

Dose of epo for EPBW

Answer 24

500-1000

Question 25

Percentage of people with kernixterus who are dx with g6pd

Answer 25

20 percent

Question 26

Sacrococcygeal tumors are highly x and can lead to high output x

Answer 26

Vascular
Cardiac failure

Question 27

Sickle cell is caused by homozygous x or co inheritance with x

Answer 27

HbSS
HbS with another beta globin variant

Question 28

TMD occurs in up to x percent of people with DS

Answer 28

Ten

Question 29

The earliest fraction of Bili is derived from x

Answer 29

Turnover of heme precursors

Question 30

Equation to calculate volume of rbc needed to get a desired crit

Answer 30

Weight times 1.6 * (desired crit minus actual crit )

Question 31

CRIT nadir for healthy term babies is when

Answer 31

8 weeks