GI Flashcards
Most promising treatment for GALD
In utero IVIG
Site of maximal B12 absorption
Ileum
Intestine -> Antibacterial substance that interacts preferentially with phospholipids in microbial cell membranes leading to lysis is
Alpha defensin
Most common malformation in syndromic or complex CHD
Cardiac
Complication of metoclopramine neonates
Neuromuscular dystonia
Most likely inheritance pattern of GALD
Maternal alloimmune disorder affecting the fetus
Genetic causes of TEA are found in x percent of cases with established links to multiple syndromes
6-10 percent
ELBW Cochrane review on time to reach full feeds comparing intermittent and continuous gastric feeding
No difference
Which practice has been associated with centers that have higher survival of patients with CDH
Permissive hypercapnia
In the case of an anterior anus in a female, the fistula opening is most likely located in the x
Perineal body
What urine test may indicate severe NEC if high?
Intestinal fatty acid binding protein I FABP. Think fodmap diet
Does the fetal intestine respond more or less robustly to bacterial components like lps?
More
GALD- organ most spared from iron deposition
Spleen
Hormone most important for regulation of intestinal transit in the process of intestinal adaptation is
Glucagon like peptide 2 We’re moving and this requires sugar
Which surgical approach is the preferred one for separating the Gi tract from the reproductive and urinary tracts ?
Posterior Sagittal approach
GI motility - older versus preterm neonates phasic activity
Preterm - clusters of low amplitude non propagating pressure waves during phase three (fasting)
Term- regular phasic propagating activity as one of the phases of phase three
Which contaminant in probiotics has caused NEC and death?
Rhizopus
What gene is involved in alagille ?
JAGGED 1 alligator has jagged teeth
A decrease in colonization of what bacteria has been observed in stool samples of preterm neonates who later develop NEC ?
Firmicutes Want to be cute
CDH is a prominent feature of what syndrome ?
Fryns - Michelle, lets be friends
What can help fecal in continence in people with anorectal malformations?
Comprehensive bowel regimens
Which elements should be reduced in TPN in a patient with cholestasis ?
Manganese and copper
The primary substrate used by enterocytes in the process of intestinal adaptation
Glutamine gluttonous glutamine
What is a valid marker of CDH severity on US?
Lung to head ratio on the contralateral area of the two dimensional lung to head circumference measured with US (22-26 weeks)
Is an esophagram necessary post EA repair ?
No. Not mandatory before initiation of feedings. And omission rarely influences clinical management
What to do after birth on patient with omphalocele?
Protect it with saline soaked dressing and place in a bowel bag
Risk factors for gastroschisis
Maternal smoking, young age, alcohol use, illicit substance use, use of over the counter vaso active meds and multiple genes implicated
Which protein predictive marker is decreased in a patient who has NEC ?
Inter alpha inhibitor protein
What study can diagnose intestinal strictures post NEC ?
Contrast study
What mode of delivery is generally advocated for in giant omphaloceles ?
C section
GALD occurs after x weeks of gestation, concurrent with the onset of active trans placental immunoglobulin x transfer which starts at x weeks gestation
18
G
12
Gastroschisis is associated with preterm birth in x percent of cases
30 percent
Is GALD A spectrum?
Yes. Could have liver disease without extra hepatic siderosis
Best serum marker reflective of enterocyte maturation in intestinal adaptation is what amino acid
Citrulline your intestine better mature after being sprayed with citrus!
Two species most associated with Dec NEC in probiotics
Lactobacillus and bifidobacterium
