Endo

Question 1

The thyroid related hormone most readily transferred across the placenta is

Answer 1

Thyrotropin releasing hormone . Sending the troops across the placenta

Question 2

What value of serum TSH is concerning for permanent congenital hypothyroidism ?

Answer 2

More than 40

Question 3

Optimal age to determine baseline thyroid function in normal neonate

Answer 3

24 hours - think newborn screen

Question 4

More than x percent of newborns born at term to mothers with Graves’ disease may have subclinical thyrotoxicosis with free t4 above 90th percentile peaking on day x

Answer 4

90th
5

Question 5

What positive test would indicate a newborn has basal insulin secretion problem

Answer 5

Positive glycemic response to IV glucagon during hypoglycemia

Question 6

T3 and T4 increase after birth, peaking at x hours

Answer 6

7

Question 7

Corticosteroids like hydrocortisone inc blood pressure by inhibiting metabolism of what

Answer 7

Catecholamines. So they are not re uptaken

Question 8

99% of whole body calcium is contained inwhat system?

Answer 8

Skeletal

Question 9

Best blood test to assess thyroid function in premie

Answer 9

Free thyroxine. The fork functions

Question 10

Bifid scrotum, blind vaginal pouch, cryptorchidism, and hypospadias are all component of what?

Answer 10

Undervirilization

Question 11

Which antithyroid drug is preferred in the first trimester?

Answer 11

Ptu

Question 12

Afterbirth, enzymes for glycogenolysis and ketogenesis will be switching on to

Answer 12

Facilitate glucose release and production of ketone bodies

Question 13

Ambiguous genitalia, 46 xy, cleft palate, polydactyl deficiency of 7 dehydrocholesterol reductase

Answer 13

Smith lemni opitz syndrome

Question 14

Thyroid related Hormone most likely to show a higher concentration in premature infants

Answer 14

Thyroglobulin. Premies look like goblins.

Question 15

In congenital hyper insulinism what imaging is helpful to identify localization of lesions before surgery?

Answer 15

PET

Question 16

What does amino phylline do to T4 and T3 levels ?

Answer 16

Increase think caffeine symptoms

Question 17

Most serious adverse effect of severe (>500) hyperglycemia is

Answer 17

ICH from hyperosmolarity

Question 18

How much calcium and phosphorus does breast milk have compared to specialty preterm formulas ?

Answer 18

1/5

Question 19

Incidence of hyperthyroidism amongst neonates born to mothers with Graves’ disease

Answer 19

1percent

Question 20

Neonates with x tubular resorption of phosphate, x parathyroid hormone levels, And hypo phosphatatemia will benefit from phos supplementation

Answer 20

High
Low to normal

Question 21

What does gkucokinase do as part of glucose regulation?

Answer 21

Glucose phosphorylation which is the rate limiting step controlling glucose regulated insulin secretion

Question 22

calcium levels are typically x in neonates with metabolic bone disease

Answer 22

Normal

Question 23

Stimulation of phallic enlargement and testicular descent is most attributed to

Answer 23

Fetal pituitary luteinizing hormone

Question 24

During what week does the fetal thyroid gland start secreting thyroid hormone

Answer 24

12 weeks

Question 25

For all gestational ages, T4 sulfate levels peak at postnatal day x and there after decrease

Answer 25

7

Question 26

The key thyroid enzyme in the neonate inhibited by maternal anti thyroid drugs is

Answer 26

Thyroid peroxidase - make sure you have your pear ox for breakfast with your medicine

Question 27

In gestation, the inner fetal zone of the adrenal cortex makes up what percent of the cortex and makes androgens

Answer 27

Eighty

Question 28

To asses bone health, rec is what imaging and what is limitation

Answer 28

Wrist or knee XR and demineralization is not apparent until at least twenty percent of bone loss has occurred

Question 29

The earliest event in the thyroid hormone production to develop in the fetus is

Answer 29

Thyroglobulin synthesis

Question 30

Why do epi and nor epi promote hyperglycemia?

Answer 30

Stress reactive hormones that inhibit insulin secretion and insulin action