Endo Flashcards
The thyroid related hormone most readily transferred across the placenta is
Thyrotropin releasing hormone . Sending the troops across the placenta
What value of serum TSH is concerning for permanent congenital hypothyroidism ?
More than 40
Optimal age to determine baseline thyroid function in normal neonate
24 hours - think newborn screen
More than x percent of newborns born at term to mothers with Graves’ disease may have subclinical thyrotoxicosis with free t4 above 90th percentile peaking on day x
90th
5
What positive test would indicate a newborn has basal insulin secretion problem
Positive glycemic response to IV glucagon during hypoglycemia
T3 and T4 increase after birth, peaking at x hours
7
Corticosteroids like hydrocortisone inc blood pressure by inhibiting metabolism of what
Catecholamines. So they are not re uptaken
99% of whole body calcium is contained inwhat system?
Skeletal
Best blood test to assess thyroid function in premie
Free thyroxine. The fork functions
Bifid scrotum, blind vaginal pouch, cryptorchidism, and hypospadias are all component of what?
Undervirilization
Which antithyroid drug is preferred in the first trimester?
Ptu
Afterbirth, enzymes for glycogenolysis and ketogenesis will be switching on to
Facilitate glucose release and production of ketone bodies
Ambiguous genitalia, 46 xy, cleft palate, polydactyl deficiency of 7 dehydrocholesterol reductase
Smith lemni opitz syndrome
Thyroid related Hormone most likely to show a higher concentration in premature infants
Thyroglobulin. Premies look like goblins.
In congenital hyper insulinism what imaging is helpful to identify localization of lesions before surgery?
PET
What does amino phylline do to T4 and T3 levels ?
Increase think caffeine symptoms
Most serious adverse effect of severe (>500) hyperglycemia is
ICH from hyperosmolarity
How much calcium and phosphorus does breast milk have compared to specialty preterm formulas ?
1/5
Incidence of hyperthyroidism amongst neonates born to mothers with Graves’ disease
1percent
Neonates with x tubular resorption of phosphate, x parathyroid hormone levels, And hypo phosphatatemia will benefit from phos supplementation
High
Low to normal
What does gkucokinase do as part of glucose regulation?
Glucose phosphorylation which is the rate limiting step controlling glucose regulated insulin secretion
calcium levels are typically x in neonates with metabolic bone disease
Normal
Stimulation of phallic enlargement and testicular descent is most attributed to
Fetal pituitary luteinizing hormone
During what week does the fetal thyroid gland start secreting thyroid hormone
12 weeks
For all gestational ages, T4 sulfate levels peak at postnatal day x and there after decrease
7
The key thyroid enzyme in the neonate inhibited by maternal anti thyroid drugs is
Thyroid peroxidase - make sure you have your pear ox for breakfast with your medicine
In gestation, the inner fetal zone of the adrenal cortex makes up what percent of the cortex and makes androgens
Eighty
To asses bone health, rec is what imaging and what is limitation
Wrist or knee XR and demineralization is not apparent until at least twenty percent of bone loss has occurred
The earliest event in the thyroid hormone production to develop in the fetus is
Thyroglobulin synthesis
Why do epi and nor epi promote hyperglycemia?
Stress reactive hormones that inhibit insulin secretion and insulin action
