2022 NeoReviews Flashcards
Findings of macrocephaly, split sutures, and thumb adduction in a male infant suggest what diagnosis ?
X linked hydrocephalus
Next best diagnostic step for baby who may have osteomyelitis is…
Ultrasound of joint
CCHD screening has low sensitivity for the detection of which 4 heart lesions?
Interrupted aortic arch, coarctation of the aorta, double outlet RV, ebstein anomaly
The presence of bone stippling and cataracts in newborn with skeletal dysplasia points to what dx?
Zellweger syndrome
When concerned for congenital cutaneous candidiasis, co- treat for … and so the empiric therapy is?
Staph
Amphotericin B, nafcillin, gentamicin
PTPN11 pathogenic variant is associated with what syndrome ?
Noonan (have inc nuchal translucency)
IUGR at risk for chronic (what organ) disease ?
Kidney
If a baby’s only manifestation of congenital CMV is sensorineural HL do you treat ?
No
Serial hearing exams
Hemolysis can occur with NEC due to activation of what antigen?
T antigen
Shoulder adduction with PICC in what vein will have catheter tip move outward ?
Cephalic (outward) and basilic (inward). Alphabetic
The risk of a coexisting hepatic hemangioma is increased with the presence of how many infantile hemangiomas ?
5 or more US their liver
First step for managing congenital nasal pyriform aperture stenosis ?
Conservative like steroids
Recommendation for hep B if you’re born at less than 2kg?
At 30 days of life or discharge , whichever is first
After resection of a thoracic teratoma, how do you monitor for recurrence or metastatic spread ?
Serial serum AFP
Infants with surfactant protein B deficiency usually die without …
Lung transplant (with it , 5 year survival is >50 percent)
Blood group inheritance phenotypes are
A, B,AB, O
Square would be at top - A,B, O and same at the sides. Each gets two alleles - O is recessive so need TWO alleles to be O
t18 -> those who survive the first year are likely to survive to age …
5 years
What makes you a low risk BRUE? Can be observed in ED
Older than 60 days, born >32 weeks, only one BRUE, lasts <1 min, no official CPR, no concerning hx, physical findings
Blunting of top flow Column on ventilator suggests what is not long enough?
I time
What is the dx when Serial measurements show increasingly elevated TSH and hypothyroxinemia and what to do?
Congenital hypothyroid
Levo
Maternal treatment with what has the highest chance of preventing ICH in a fetus with NAIT?
IVIG
Strategies to reduce conductive heat loss include
Warm blanket
Chemical mattress
? Has high sensitivity and specificity as a marker for BA in infants older than 30 days
Matrix metalloproteinase-7
What may ameliorate liver injury and therefore symptoms in patient with zellweger syndrome?
Cholic acid (give back bile acids )
NRP PRE birth questions (4)
GA
color amniotic fluid
Risk factors
Umbilical cord management
Calculation of partial exchange (total blood volume to be exchanged to achieve a goal crit of 55)
(Total blood volume mL x observed CRIT - desired crit) / observed crit
Of note, TBV is 80 per kilo
HFOV -> frequency is related to TV HOW?
Inversely
When do eyelids begin to separate after being fused ?
Week 22 and takes 3-6 weeks in utero to complete. If born takes 5 days
Neonatal Graves’ disease is mediated by antibodies to …
Thyroid stimulating hormone receptor antibodies (TRab) baby would be hyperthyroid
Poisseulles law
How does resistance affect mean airway pressure ?
Resistance = length of tube/ radius ^4
Higher resistance, lower MAP
Milrinone- what type of med? How does it increase cardiac output?
Phosphodiesterase 3 inhibitor
Inc myocardial stroke volume by better diastolic relaxation = lucitropy
Primary mechanism for anti inflammatory effect of CLD of glucocorticoids?
Genomic mechanisms
Half life of nadolol?
Five days
When to give rotavirus
6-15 weeks after birth , 2-3 doses,
Finished by 8 months old
What virus can manifest with diarrhea, ileus, meningitis, seizures and apnea ?
Parecho virus
First step in finding etiology of congenital nephrotic syndrome (proteinuria, swelling, large kidneys)
Genetic testing
Best way to estimate ETT depth
GA nomogram
When to consider methemoglobinemia?
Cyanosis unresponsive to O2 and chocolate blood when exposed to air
Third trimester fetal protein accretion ?
4 g per kilo per day
? Mediated Brady is common side effect of precedex?
Baro receptor mediated reflex Brady
If discharged with hx stage 1 AKI what is appropriate follow up?
Cr in three months
Rocuronium is an acetylcholine? And sugammadex? Paralysis without associated ? Effects
Antagonist
Reverses
Muscarinic (Brady and bronchospasm)
During an evacuation for disaster, first step is ?
Assigning incident commander
Encephalopathy on exam of a patient with SGH is a key predictor of early ?
Mortality
