HEME Flashcards
Iron low
TIBC/ Transferrin high
Ferritin low
Iron Deficiency
Iron low
TIBC/ Transferrin low
Ferritin high
Chronic Disease
Physical exam findings of iron def
Kiolnychia
Angular Cheilosis
Tachycardia - heart is pumping harder with low o2
Glossitis
EKG of IRON deficiency
Global ST depression
Treatment for Thalassemia
Blood transfusions but ultimately splenectomy
key terms - kid with pica
Lead poisoning
Alcoholic with microcytic
Sideroblastosis
Name all the microcytic anemias
Iron def
Thalamssemia
Lead poisoning
Sideroblastosis
Name all the Normocytic Nomrochromic anemias
Chronic disease
- kidney disease
- infection
Name all the hemolytic anemia
Sickle cell
G6PD
what genetic disorder is sickle cell
X-linked recessive
which anemia
Bilirubin high
LDH high
Haptoglobin low
Hemolytic anemias
usually -> Sickle cell
Parvovirus B19 commonly causes what anemia
Aplastic Anemia
pancytopenia
shuts down the bone marrow
What is vasooculsive crisis
From massive sickle cells
- > acute chest syndrome
- > Pain in joints, ABD
- > Pripsm
- > stoke
What is the most lethal complication of sickle cell crisis
acute chest syndrome
they are tiny infarcts happening in the chest
Treatment for sickle cell
Hydroxurea
DONT GIVE NSAIDS LIKE TORADOL- will shut down kidneys
What does Hydroxurea do?
Increases the amount of Fetal Hemoglobin
really important for Sickle cell anemia
What causes G6PD
Fava beans Dapsone Primaquine Sulfonamides- bactrium Chloriquines Primaquine
Another name for Factor 8 deficiency
Hemophilia A
Another name for Factor 9 deficiency
Hemophilia B
What genetic disorder is Hemophilia
X-linked Recessive
Mendelian genetics
What is the hallmark of Hemophilia
Think kid with no history of trama
with red joint
not swollen but painful
What is the dose for Factor 8 deficency
mild
Moderate
severe
12.5
25
50
What is the dose for Factor 9 deficency
mild
Moderate
severe
25
50
100
Most common inherited bleeding disorder
Von Willebrand disease
Plts normal
Bleeding time - prolonged
PT normal
PTT normal
Von Willebrand disease
von williebrand activity level- decreased * most important test
Treatment for Von Willebrand disease
Cryoparcipitate F8 itself DDAVP *Tranexamic Acid- Block fibrinolysis *Amino-Caproic Acid - Blocks fibrinolysis