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RUSVM Pathology II > Hematopoietic System Pathology > Flashcards

Hematopoietic System Pathology Flashcards

1
Q

Morphological diagnosis

A

Acute multifocal necrotizing hepatitis and splenitis

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2
Q

Splenomegaly caused by

A

Amyloidosis

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3
Q

Indications for examining bone marrow

A

Unexplained cytopenia

Maturation defects or morphologic abnormalities in blood cells

Potential myelo/lympho-proliferative disease

Potential malignancies

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4
Q

Condition

A

Splenic Hemangioma

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5
Q

Etiology of Strangles

A

Streptococcus equi subsp equi

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6
Q

Condition

A

Multiple “Spleens”

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7
Q

Autosomal recessive bone marrow disorder that disrupts the sequence of steps leading to the migration of leukocytes into sites of inflammation leading to bone marrow hyperplasia

A

Bovine Leukocyte Adhesion Deficiency Syndrome - BLAD

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8
Q

Differential diagnosis for hyperplastic splenitis

A

Aleutian Disease

Equine Infectious Anemia

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9
Q

Differential diagnosis for splenic thrombosis/ infarction

A

Classicial Swine Fever (Hog Cholera)

Lymphosarcoma

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10
Q

Splenic nodules with a blood consistency can be

A

Hematomas

Incompletely contracted areas of spleen

Acute splenic infarcts

Vascular neoplasms

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11
Q

Bloody spleen can be generally caused by

A

Congestion

Acute Hyperemia

Acute Hemolytic Anemia

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12
Q

Disease in pigs that causes diffuse granulomatous lymphadenitis

A

Postweaning Multisystemic Wasting Disease

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13
Q

Morphological Diagnosis

A

Necrotizing splenitis

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14
Q

Malignant bone marrow neoplasm of histiocytic origin.

A

Histocytic Sarcoma

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15
Q

Disease in which carbon particles are retained in macrophages, medulla of lymph node appears black.

A

Anthracosis

________________________________

Common finding in animals living in polluted urban areas

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16
Q

Disease of the spleen that causes necrotizing splenitis characterized by white-grey milliary foci scarttered throughout the splenic parenchyma.

A

Tularemia - Rabbit Fever

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17
Q

Condition

A

Histiocytic Sarcoma

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18
Q

Hemal Nodes

A

Prominant in ruminants, small, dark red similar architecture

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19
Q

Bone Marrow Hypoplasia/ Atrophy may be the result of

A

Myelophthisis

Abnormality of hematopoietic cells

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20
Q

Etiology of Cytauxzoonosis

A

Cytauxzoon felis

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21
Q

Disease

A

Multiple Myeloma

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22
Q

Condition

A

Splenic hemangiosarcoma

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23
Q

Etiology

A

Histoplasma capsulatum

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24
Q

Disease that causes granulomatous lymphadenitis characterized by B and T lymphoid depletion and “botryoid” intracytoplasmic inclusions in macrophages.

A

Post Weaning Multisystemic Wasting Disease - PMWD

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25
Q

Etiology of granulomatous splenitis

A

Mycobacterium avium

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26
Q

Etiologic Agent and Disease

A

Francisella tularensis

Tularemia

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27
Q

Disease of the raptors characterized by acute multifocal milliary necrotizing hepatitis and splenitis.

A

Herpes Inclusio Body Disease - Hepatosplenitis

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28
Q

Splenic infarction in pigs is an indication of what disease

A

Classical Swine Fever - Hog Cholera

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29
Q

Disease caused by the organism in these tissue aspirates of the lymph node and spleen of a cat

A

Cytauxzoonosis

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30
Q

Dogs with benign splenic masses had a significantly (higher/lower) mean to splenic volume ration and (higher/lower) splenic weight as a percentage of body weight than did dogs with hemangiosarcoma.

A

Dogs with benign splenic masses had a significantly (higher/lower) mean to splenic volume ration and (higher/lower) splenic weight as a percentage of body weight than did dogs with hemangiosarcoma.

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31
Q

Lesion associated with this lymph node asipirate

A

Granulomatous Lymphadenitis

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32
Q

Splenomegaly due to diffuse enlargement can be due to

A

Congestion

Cell proliferation/ infiltration

Accumulation of extracellular material

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33
Q

Lesion

A

Granulomatous Lymphadenitis

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34
Q

Disease characterized by mandibular, pharyngeal, parotid lymph node abscesation and fistulization

A

Strangles

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35
Q

Morphological Diagnosis

A

Bone Marrow Hyperplasia

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36
Q

Disease of 3-6 week old chicks that causes lymphoid depletion by targeting pre-B lymphocytes

A

Infectious Bursal Disease (IBD)

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37
Q

Disease of the spleen characterized by grey-white to yellow, hard dry encrustations on the capsule, usually along the margins of teh spleen but can be elsewhere.

A

Siderofibrosis

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38
Q

Disease of equids characterized by abscesses anywhere in the body other than the pharyngeal area

A

Bastard Strangles

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39
Q

Condition

A

Splenic Hematoma

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40
Q

Lymph node abscess in a horse what is the etiology?

A

Streptococcus equi subsp equi

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41
Q

Pathogenesis of Bone Marrow Hyperplasia

A

Increased cell production in the marrow in response to poietins and interleukins → decreased cell numbers in blood caused by increased peripheral demand → adequate numbers of hypofunctional cells in peripheral blood

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42
Q

Etiology of Anthrax

A

Bacillus anthracis

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43
Q

Bone marrow necrosis may result in what clinical pathology finding?

A

Pancytopenia

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44
Q

Lesions associated with what disease of chickens?

A

Marek’s Disease

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45
Q

Abnormality

A

None - normal active bone marrow

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46
Q

Disease characterized by increased yellow marrow and is usually accompanied by marrow degeneration. Clinical pathology findings include anemia, neutropenia, thrombocytopenia.

A

Bone Marrow Hypoplasia / Atrophy

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47
Q

Differential Diagnosis for hemosiderosis of the spleen

A

Decreased rate of erythropoiesis

Rapid destruction of RBC

Chronic heart failure

Iron dextran injection

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48
Q

Brownish discoloration observed in lymph nodes draining areas of hemorrhage

A

Hemosiderosis

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49
Q

Etiology of Caseous Lymphadenitis

A

Corynebacterium pseudotuberculosis

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50
Q

Condition

A

Lymphoid Hyperplasia

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51
Q

(Cutaneous / Extramedullary) Plasmacytomas are typically malignant

A

Extramedullary Plasmacytomas

52
Q

Disease

A

Multiple Myeloma

53
Q

Etiology of Infectious Bursal Disease (IBD)

A

Avian Bursal Disease Virus

54
Q

Condition

A

Thymic Lymphosarcoma

55
Q

Disease of the spleen that causes acute splenitis. It is characterized by acute death, bloated carcass, rapid-post mortem autolysis and blood oozing from body orifices.

A

Anthrax

56
Q

Likely etiology of suppurative osteomyelitis

A

Bacterial infection

57
Q

Differential Diagnosis for focal areas of necrosis in lymph node

A

Yersina Pestis

Toxoplasmosis

Salmonellosis

Tularemia

Tyzzer’s Disease

Feline Infectious Peritonitis

58
Q

Disease of the bone marrow that is often fatal due to occulusion of lumina of vessles in the lung, brain, liver, lymph node and spleen.

A

Cytauxzoonosis

59
Q

Etiology of Tularemia

A

Francisella tularensis

60
Q

Normal Myeloid: Erythroid Ratio

A

1.5 : 1

61
Q

What should you evaluate on a core biopsy of bone marrow

A

Cellularity

Myeloid: Erythroid Ratio

62
Q

Disease and Etiology

A

Granulomatous Splenitis

Mycobacterium avium

63
Q

Etiology of bubonic plague

A

Yersinia pestis

64
Q

Possible causes of bone marrow hyperplasia

A

Bovine Leukocyte Adhesion Deficiency Syndrome - BLAD

IHA

Equine Infectious Anemia

65
Q

Spleen of a cow that acutely died and was found bloated what is the most likely disease?

A

Anthrax

66
Q

Disease

A

Bone Marrow Lymphoma

67
Q

Condition

A

Splenic Lymphosarcoma

68
Q

Condition

A

Thymic Lymphoma

69
Q

Common features of myelo/lympho-proliferative disease

A

Anemia

Hypercellular Marrow

Leukemic Cells in peripheral circulation

Megaloblastic alteration in erythroid cells

Thrombocytopenia

Hepato/Spleno-megaly

70
Q

During gestation, hematopoietic cells originate in the

A

Liver, Spleen and Bone Marrow

71
Q

Disease of 2-5 month old chickens characterized by lymphocytic infiltrates and peripheral neuritis.

A

Marek’s Disease

72
Q

Condition

A

Splenic Hemangiosarcoma

73
Q

Etiology of Herpes Inclusion Body Disease

A

Columbid Herpesvirus 1 (CoHV-1)

74
Q

Condition

A

Thymoma

75
Q

Differential Diagnosis for Acute Passive Congestion of the spleen

A

Barbiturate induced

Equine Infectious Anemia

Gastrosplenic Torsion/ Volvulus

76
Q

Malignant tumor of plasma cells that secretes Ig/Ig subunit. It is characterized by increased numbers of plasma cells in BM, monoclonal gammopathy, osteolysis, light chain proteinuria, hypercalcemia, cytopenias, and renal amyloidosis.

A

Multiple Myeloma

77
Q

Disease characterized by painful, swollen lymph nodes with focal areas of necrosis.

A

Bubonic Plague

78
Q

Meat spleen can be generally caused by

A

Phagocytosis

Proliferation of Cells

Storage of material

79
Q

Disease of equines that is characterized by immune mediated hemolysis and decreased erythropoeisis leading to bone marrow hyperplasia

A

Equine Infectious Anemia

80
Q

Primary neoplasias of the bone marrow are divided into

A

Lymphoproliferative Disorders

Myeloproliferative Disorders

81
Q

Condition

A

Splenosis

______________________________

Splenic rupture lead to seeding of the omentum and formation of numerous “accessory spleens”

82
Q

Splenic nodules with a firm consistency could be

A

Splenic nodular hyperplasia

Fibrohistiocytic nodules

Primary neoplasms

Secondary neoplasms

Granulomas

Abscesses

83
Q

Etiology

A

Bovine Enzootic Leukosis

84
Q

Degenerative lesion of the spleen

A

Siderofibrosis

85
Q

Likely etiology of granulomatious osteomyelitis

A

Fungal infection

86
Q

Splenic rupture leading to seeding of the omentum and formation of numerous accessory spleens

A

Splenosis - Splenic Rupture

87
Q

Differential diagosis for thymic atrophy

A

EHV 1

FeLV

Feline Panleukemia

BVD

Canine Distemper

88
Q

Disease of chickens that is characterized by the proliferation of B lymphocytes.

A

Lymphoid Leukosis

89
Q

Possible DDX

A

Multiple Myeloma

Osteomyelitis

90
Q

Disease

A

Lymphosarcoma

91
Q

Etiology

A

Corynebacterium pseudotuberculosis

92
Q

Replacement of myeloid tissue by abnormal tissue

A

Myelophthisis

93
Q

(Lympho/Myelo)-proliferative diseases are more common.

A

Lymphoproliferative Diseases

94
Q

Disease characterized by greenish coored pus that becomes caseous with age.

A

Caseous Lymphadenitis

95
Q

Etiology of Marek’s Disease

A

Herpesvirus

96
Q

Two common locations for hemangiosarcomas

A

Subcutis

Right Atrium

97
Q

Disease

A

Caseous Lymphadenitis

98
Q

Condition

A

Nodular Hyperplasia

99
Q

Common disease that causes Myelophthisis

A

Scurvy - Vitamin C Deficiency

100
Q

Differential Diagnosis for thymic hypoplasia

A

Severe Combined Immunodeficiency (SCID)

X- Linked Gene

101
Q

Describe the appearance of porcine lymph nodes

A

Inverted cortex and medulla

102
Q

Disease

A

Serous Atrophy of Fat

103
Q

Rare neoplasm of the bone marrow that is usually benign and of the skin or mucous membrane origin.

A

Cutaneous Plasmocytoma

104
Q

Non neoplastic canine immunoregulatory disorders

A

Cutaneous Histocytosis

Systemic Histocytosis

105
Q

Condition

A

Histiocytic Sarcoma

106
Q

Disease of the spleen caused by chronic antigenic stimulation leading to hyperplasia of the monocyte-macrophage or lymphoid/plasma cell population

A

Hyperplastic splenitis

107
Q

Etiology

A

Mycobacterium bovis

108
Q

Disease

A

Suppurative Osteomyelitis

109
Q

Lesion

A

Myelofibrosis

___________________

Can be caused by Scurvy in guinea pigs

110
Q

In the embryo, hematopoietic cells originate in the

A

Yolk Sac

111
Q

Differential diagnosis for granulomatous lymphadenitis

A

Mycobacterium bovis

Histoplasma capsulatum

Post weaning Multisystemic Wasting Disease

112
Q

Disease characterized by hyperplastic cell lines (one or multiple) and red marrow replacement by yellow marrow.

A

Bone Marrow Hyperplasia

113
Q

Pathogenesis of Cytauxzoonosis

A

Schizogenous phase → Macrophages = Systemic Illness

Erythrocytic phase = Anemia

114
Q

Etiology of Lymphoid leukosis in chickens

A

Avian Leukosis Virus

115
Q

Bone marrow disease characterized by ineffective and dysplastic hematopoiesis. Diagnosed based on presence of decreased blasts in bone marrow ( < 30%), cytopenia of > 1 cell line and evidence of dyshematopoiesis.

A

Myelodysplastic Syndrome (MDS)

116
Q

Release of immature cells from the bone marrow indicates

A

Stress or disease

117
Q

The bursa of fabricius is populated by what type of lymphocytes

A

B lymphocytes

118
Q

Main components of the hematopoietic system

A

Bone marrow

Blood cells

Lymph nodes and lymphatics

Spleen

Mucosa Associated Lymphoid Tissue (MALT)

Thymus

119
Q

Clinical pathology associated with Splenic Hemangiosarcomas

A

Anemia

Thrombocytopenia

Increased hepatic enzymes

Schistocytes

120
Q

Differential diagnosis for nodular hyperplasia

A

Lymphoma

Granulomatous infection

121
Q

Histologic lesion associated with pigs infected with PMWS

A

“Botryoid” Intracytoplasmic Inclusions in Macrophages

122
Q

Primary neoplasia of the lymphnode characterized by mottled pale tane and red appearance that is slightly buldging and nodular.

A

Lymphosarcoma

123
Q

Disease and etiology

A

Herpes inclusion body disease

Columbid herpesvirus 1 (CoHV-1)

124
Q

Etiology

A

Bacillus anthracis

125
Q

Indolent cutaneous neoplasm of bone marrow. Probably of dendritic cell origin

A

Feline Progressive Histiocytosis

126
Q

Splenomegaly caused by

A

Barbiturate euthanasia

RUSVM Pathology II (12 decks)

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